Cargando…
Insights into the Architecture of the eIF2Bα/β/δ Regulatory Subcomplex
[Image: see text] Eukaryotic translation initiation factor 2B (eIF2B), the guanine nucleotide exchange factor for the G-protein eIF2, is one of the main targets for the regulation of protein synthesis. The eIF2B activity is inhibited in response to a wide range of stress factors and diseases, includ...
Autores principales: | Bogorad, Andrew M., Xia, Bing, Sandor, Dana G., Mamonov, Artem B., Cafarella, Tanya R., Jehle, Stefan, Vajda, Sandor, Kozakov, Dima, Marintchev, Assen |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045321/ https://www.ncbi.nlm.nih.gov/pubmed/24811713 http://dx.doi.org/10.1021/bi500346u |
Ejemplares similares
-
Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation
por: Bogorad, Andrew M., et al.
Publicado: (2017) -
Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2
por: Kuhle, Bernhard, et al.
Publicado: (2015) -
Comparative sequence and structure analysis of eIF1A and eIF1AD
por: Yu, Jielin, et al.
Publicado: (2018) -
Evidence of Conformational Selection Driving the Formation of Ligand Binding Sites in Protein-Protein Interfaces
por: Bohnuud, Tanggis, et al.
Publicado: (2014) -
Fragments and hot spots in drug discovery
por: Vajda, Sandor, et al.
Publicado: (2015)