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Building a secreting nanomachine: a structural overview of the T3SS()

To fulfill complex biological tasks, such as locomotion and protein translocation, bacteria assemble macromolecular nanomachines. One such nanodevice, the type III secretion system (T3SS), has evolved to provide a means of transporting proteins from the bacterial cytoplasm across the periplasmic and...

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Detalles Bibliográficos
Autores principales: Abrusci, Patrizia, McDowell, Melanie A, Lea, Susan M, Johnson, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045390/
https://www.ncbi.nlm.nih.gov/pubmed/24704748
http://dx.doi.org/10.1016/j.sbi.2013.11.001
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author Abrusci, Patrizia
McDowell, Melanie A
Lea, Susan M
Johnson, Steven
author_facet Abrusci, Patrizia
McDowell, Melanie A
Lea, Susan M
Johnson, Steven
author_sort Abrusci, Patrizia
collection PubMed
description To fulfill complex biological tasks, such as locomotion and protein translocation, bacteria assemble macromolecular nanomachines. One such nanodevice, the type III secretion system (T3SS), has evolved to provide a means of transporting proteins from the bacterial cytoplasm across the periplasmic and extracellular spaces. T3SS can be broadly classified into two highly homologous families: the flagellar T3SS which drive cell motility, and the non-flagellar T3SS (NF-T3SS) that inject effector proteins into eukaryotic host cells, a trait frequently associated with virulence. Although the structures and symmetries of ancillary components of the T3SS have diversified to match requirements of different species adapted to different niches, recent genetic, molecular and structural studies demonstrate that these systems are built by arranging homologous modular protein assemblies.
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spelling pubmed-40453902014-06-06 Building a secreting nanomachine: a structural overview of the T3SS() Abrusci, Patrizia McDowell, Melanie A Lea, Susan M Johnson, Steven Curr Opin Struct Biol Article To fulfill complex biological tasks, such as locomotion and protein translocation, bacteria assemble macromolecular nanomachines. One such nanodevice, the type III secretion system (T3SS), has evolved to provide a means of transporting proteins from the bacterial cytoplasm across the periplasmic and extracellular spaces. T3SS can be broadly classified into two highly homologous families: the flagellar T3SS which drive cell motility, and the non-flagellar T3SS (NF-T3SS) that inject effector proteins into eukaryotic host cells, a trait frequently associated with virulence. Although the structures and symmetries of ancillary components of the T3SS have diversified to match requirements of different species adapted to different niches, recent genetic, molecular and structural studies demonstrate that these systems are built by arranging homologous modular protein assemblies. Elsevier Science 2014-04 /pmc/articles/PMC4045390/ /pubmed/24704748 http://dx.doi.org/10.1016/j.sbi.2013.11.001 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Abrusci, Patrizia
McDowell, Melanie A
Lea, Susan M
Johnson, Steven
Building a secreting nanomachine: a structural overview of the T3SS()
title Building a secreting nanomachine: a structural overview of the T3SS()
title_full Building a secreting nanomachine: a structural overview of the T3SS()
title_fullStr Building a secreting nanomachine: a structural overview of the T3SS()
title_full_unstemmed Building a secreting nanomachine: a structural overview of the T3SS()
title_short Building a secreting nanomachine: a structural overview of the T3SS()
title_sort building a secreting nanomachine: a structural overview of the t3ss()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045390/
https://www.ncbi.nlm.nih.gov/pubmed/24704748
http://dx.doi.org/10.1016/j.sbi.2013.11.001
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