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Hepatitis C Virus Infection and Dialysis: 2012 Update
Hepatitis C virus infection is still common among dialysis patients, but the natural history of HCV in this group is not completely understood. Recent evidence has been accumulated showing that anti-HCV positive serologic status is significantly associated with lower survival in dialysis population;...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045425/ https://www.ncbi.nlm.nih.gov/pubmed/24959533 http://dx.doi.org/10.5402/2013/159760 |
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author | Fabrizi, Fabrizio |
author_facet | Fabrizi, Fabrizio |
author_sort | Fabrizi, Fabrizio |
collection | PubMed |
description | Hepatitis C virus infection is still common among dialysis patients, but the natural history of HCV in this group is not completely understood. Recent evidence has been accumulated showing that anti-HCV positive serologic status is significantly associated with lower survival in dialysis population; an increased risk of liver and cardiovascular disease-related mortality compared with anti-HCV negative subjects has been found. According to a novel meta-analysis (fourteen studies including 145,608 unique patients), the adjusted RR for liver disease-related death and cardiovascular mortality was 3.82 (95% CI, 1.92; 7.61) and 1.26 (95% CI, 1.10; 1.45), respectively. It has been suggested that the decision to treat HCV in patients with chronic kidney disease be based on the potential benefits and risks of therapy, including life expectancy, candidacy for kidney transplant, and co-morbidities. According to recent guidelines, the antiviral treatment of choice in HCV-infected patients on dialysis is mono-therapy but fresh data suggest the use of modern antiviral approaches (i.e., pegylated interferon plus ribavirin). The summary estimate for sustained viral response and drop-out rate was 56% (95% CI, 28–84) and 25% (95% CI, 10–40) in a pooled analysis including 151 dialysis patients on combination antiviral therapy (conventional or pegylated interferon plus ribavirin). |
format | Online Article Text |
id | pubmed-4045425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40454252014-06-23 Hepatitis C Virus Infection and Dialysis: 2012 Update Fabrizi, Fabrizio ISRN Nephrol Review Article Hepatitis C virus infection is still common among dialysis patients, but the natural history of HCV in this group is not completely understood. Recent evidence has been accumulated showing that anti-HCV positive serologic status is significantly associated with lower survival in dialysis population; an increased risk of liver and cardiovascular disease-related mortality compared with anti-HCV negative subjects has been found. According to a novel meta-analysis (fourteen studies including 145,608 unique patients), the adjusted RR for liver disease-related death and cardiovascular mortality was 3.82 (95% CI, 1.92; 7.61) and 1.26 (95% CI, 1.10; 1.45), respectively. It has been suggested that the decision to treat HCV in patients with chronic kidney disease be based on the potential benefits and risks of therapy, including life expectancy, candidacy for kidney transplant, and co-morbidities. According to recent guidelines, the antiviral treatment of choice in HCV-infected patients on dialysis is mono-therapy but fresh data suggest the use of modern antiviral approaches (i.e., pegylated interferon plus ribavirin). The summary estimate for sustained viral response and drop-out rate was 56% (95% CI, 28–84) and 25% (95% CI, 10–40) in a pooled analysis including 151 dialysis patients on combination antiviral therapy (conventional or pegylated interferon plus ribavirin). Hindawi Publishing Corporation 2012-12-17 /pmc/articles/PMC4045425/ /pubmed/24959533 http://dx.doi.org/10.5402/2013/159760 Text en Copyright © 2013 Fabrizio Fabrizi. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fabrizi, Fabrizio Hepatitis C Virus Infection and Dialysis: 2012 Update |
title | Hepatitis C Virus Infection and Dialysis: 2012 Update |
title_full | Hepatitis C Virus Infection and Dialysis: 2012 Update |
title_fullStr | Hepatitis C Virus Infection and Dialysis: 2012 Update |
title_full_unstemmed | Hepatitis C Virus Infection and Dialysis: 2012 Update |
title_short | Hepatitis C Virus Infection and Dialysis: 2012 Update |
title_sort | hepatitis c virus infection and dialysis: 2012 update |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045425/ https://www.ncbi.nlm.nih.gov/pubmed/24959533 http://dx.doi.org/10.5402/2013/159760 |
work_keys_str_mv | AT fabrizifabrizio hepatitiscvirusinfectionanddialysis2012update |