Cargando…
Paracetamol Interference in Uric Acid Levels in Uremic Patients Revealed by Monitoring Spent Dialysate
The aim of this study was to assess removal dynamics of paracetamol (PAR), as an extraordinary chromophore in spent dialysate, upon the optical monitoring of dialysis of end-stage renal disease patients with inflammation complications. Seven dialysis sessions of different patients were followed to w...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045446/ https://www.ncbi.nlm.nih.gov/pubmed/24967235 http://dx.doi.org/10.5402/2013/515292 |
_version_ | 1782319322603978752 |
---|---|
author | Tanner, Risto Arund, Jürgen Fridolin, Ivo Luman, Merike |
author_facet | Tanner, Risto Arund, Jürgen Fridolin, Ivo Luman, Merike |
author_sort | Tanner, Risto |
collection | PubMed |
description | The aim of this study was to assess removal dynamics of paracetamol (PAR), as an extraordinary chromophore in spent dialysate, upon the optical monitoring of dialysis of end-stage renal disease patients with inflammation complications. Seven dialysis sessions of different patients were followed to whom PAR was used as a pain reliever or antipyretic. Spent dialysate was sampled hourly and analyzed using HPLC with MS/MS and UV detection. Quantitative calculations were made on the basis of the peak areas on the chromatograms at 280 nm for uric acid (UA) and 254 nm for PAR and its metabolites (PAR-M). Peaks of UA, PAR, PAR-glucuronide, and PAR-sulphate were identified on the basis of specific mass spectra. Removal of PAR was found to be proportional to that of uric acid if intake of the drug by patient occurred half a day before dialysis. But disturbances of the UV-absorbance curves at 280 nm were observed related to rise of UA concentration in spent dialysate when PAR was taken by patients in the course of dialysis. The mechanism of such relation remains unknown. It was concluded that possible benefits and risks of treatment of uremic patients with paracetamol-containing drugs may need to be reassessed. |
format | Online Article Text |
id | pubmed-4045446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40454462014-06-25 Paracetamol Interference in Uric Acid Levels in Uremic Patients Revealed by Monitoring Spent Dialysate Tanner, Risto Arund, Jürgen Fridolin, Ivo Luman, Merike ISRN Nephrol Clinical Study The aim of this study was to assess removal dynamics of paracetamol (PAR), as an extraordinary chromophore in spent dialysate, upon the optical monitoring of dialysis of end-stage renal disease patients with inflammation complications. Seven dialysis sessions of different patients were followed to whom PAR was used as a pain reliever or antipyretic. Spent dialysate was sampled hourly and analyzed using HPLC with MS/MS and UV detection. Quantitative calculations were made on the basis of the peak areas on the chromatograms at 280 nm for uric acid (UA) and 254 nm for PAR and its metabolites (PAR-M). Peaks of UA, PAR, PAR-glucuronide, and PAR-sulphate were identified on the basis of specific mass spectra. Removal of PAR was found to be proportional to that of uric acid if intake of the drug by patient occurred half a day before dialysis. But disturbances of the UV-absorbance curves at 280 nm were observed related to rise of UA concentration in spent dialysate when PAR was taken by patients in the course of dialysis. The mechanism of such relation remains unknown. It was concluded that possible benefits and risks of treatment of uremic patients with paracetamol-containing drugs may need to be reassessed. Hindawi Publishing Corporation 2013-10-03 /pmc/articles/PMC4045446/ /pubmed/24967235 http://dx.doi.org/10.5402/2013/515292 Text en Copyright © 2013 Risto Tanner et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Tanner, Risto Arund, Jürgen Fridolin, Ivo Luman, Merike Paracetamol Interference in Uric Acid Levels in Uremic Patients Revealed by Monitoring Spent Dialysate |
title | Paracetamol Interference in Uric Acid Levels in Uremic Patients Revealed by Monitoring Spent Dialysate |
title_full | Paracetamol Interference in Uric Acid Levels in Uremic Patients Revealed by Monitoring Spent Dialysate |
title_fullStr | Paracetamol Interference in Uric Acid Levels in Uremic Patients Revealed by Monitoring Spent Dialysate |
title_full_unstemmed | Paracetamol Interference in Uric Acid Levels in Uremic Patients Revealed by Monitoring Spent Dialysate |
title_short | Paracetamol Interference in Uric Acid Levels in Uremic Patients Revealed by Monitoring Spent Dialysate |
title_sort | paracetamol interference in uric acid levels in uremic patients revealed by monitoring spent dialysate |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045446/ https://www.ncbi.nlm.nih.gov/pubmed/24967235 http://dx.doi.org/10.5402/2013/515292 |
work_keys_str_mv | AT tannerristo paracetamolinterferenceinuricacidlevelsinuremicpatientsrevealedbymonitoringspentdialysate AT arundjurgen paracetamolinterferenceinuricacidlevelsinuremicpatientsrevealedbymonitoringspentdialysate AT fridolinivo paracetamolinterferenceinuricacidlevelsinuremicpatientsrevealedbymonitoringspentdialysate AT lumanmerike paracetamolinterferenceinuricacidlevelsinuremicpatientsrevealedbymonitoringspentdialysate |