Hyaluronan Is Not a Ligand but a Regulator of Toll-Like Receptor Signaling in Mesangial Cells: Role of Extracellular Matrix in Innate Immunity

Glomerular mesangial cells (MC), like most cell types secrete hyaluronan (HA), which attached to the cell surface via CD44, is the backbone of a hydrophilic gel matrix around these cells. Reduced extracellular matrix thickness and viscosity result from HA cleavage during inflammation. HA fragments w...

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Detalles Bibliográficos
Autores principales: Ebid, Rainer, Lichtnekert, Julia, Anders, Hans-Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045461/
https://www.ncbi.nlm.nih.gov/pubmed/24967246
http://dx.doi.org/10.1155/2014/714081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045461/
https://www.ncbi.nlm.nih.gov/pubmed/24967246
http://dx.doi.org/10.1155/2014/714081

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