Angiotensin Type-1 Receptor Blockade May Not Protect Kidney against Cisplatin-Induced Nephrotoxicity in Rats

Background. Cisplatin (CDDP) is an anticancer drug, which is accompanied with major side effects including nephrotoxicity. We tested two doses of losartan (10 and 20 mg/kg/day) against nephrotoxicity in a rat model treated with daily administration of CDDP (2.5 mg/kg/day). Methods. Five groups of ra...

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Detalles Bibliográficos
Autores principales: Rastghalam, Roya, Nematbakhsh, Mehdi, Bahadorani, Mehrnoosh, Eshraghi-Jazi, Fatemeh, Talebi, Ardeshir, Moeini, Maryam, Ashrafi, Farzaneh, Shirdavani, Soheila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045571/
https://www.ncbi.nlm.nih.gov/pubmed/24967243
http://dx.doi.org/10.1155/2014/479645

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