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Metformin Attenuates Palmitate-Induced Endoplasmic Reticulum Stress, Serine Phosphorylation of IRS-1 and Apoptosis in Rat Insulinoma Cells

Lipotoxicity refers to cellular dysfunctions caused by elevated free fatty acid levels playing a central role in the development and progression of obesity related diseases. Saturated fatty acids cause insulin resistance and reduce insulin production in the pancreatic islets, thereby generating a vi...

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Detalles Bibliográficos
Autores principales:	Simon-Szabó, Laura, Kokas, Márton, Mandl, József, Kéri, György, Csala, Miklós
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045581/ https://www.ncbi.nlm.nih.gov/pubmed/24896641 http://dx.doi.org/10.1371/journal.pone.0097868

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