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CDK9 inhibition strategy defines distinct sets of target genes
BACKGROUND: CDK9 is the catalytic subunit of the Positive Transcription Elongation Factor b (P-TEFb), which phosphorylates the CTD of RNAPII and negative elongation factors enabling for productive elongation after initiation. CDK9 associates with T-type cyclins and cyclin K and its activity is tight...
Autores principales: | Garriga, Judit, Graña, Xavier |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045923/ https://www.ncbi.nlm.nih.gov/pubmed/24886624 http://dx.doi.org/10.1186/1756-0500-7-301 |
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