Improvement of spinal non-viral IL-10 gene delivery by D-mannose as a transgene adjuvant to control chronic neuropathic pain

BACKGROUND: Peri-spinal subarachnoid (intrathecal; i.t.) injection of non-viral naked plasmid DNA encoding the anti-inflammatory cytokine, IL-10 (pDNA-IL-10) suppresses chronic neuropathic pain in animal models. However, two sequential i.t. pDNA injections are required within a discrete 5 to 72-hour...

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Detalles Bibliográficos
Autores principales: Dengler, Ellen C, Alberti, Lauren A, Bowman, Brandi N, Kerwin, Audra A, Wilkerson, Jenny L, Moezzi, Daniel R, Limanovich, Eugene, Wallace, James A, Milligan, Erin D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046049/
https://www.ncbi.nlm.nih.gov/pubmed/24884664
http://dx.doi.org/10.1186/1742-2094-11-92

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