Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity

Patients experiencing natural infection with Borrelia burgdorferi display a spectrum of associated symptoms and severity, strongly implicating the impact of genetically determined host factors in the pathogenesis of Lyme disease. Herein, we provide a summary of the host genetic factors that have bee...

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Autores principales: Bramwell, Kenneth K.C., Teuscher, Cory, Weis, Janis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046100/
https://www.ncbi.nlm.nih.gov/pubmed/24926442
http://dx.doi.org/10.3389/fcimb.2014.00076
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author Bramwell, Kenneth K.C.
Teuscher, Cory
Weis, Janis J.
author_facet Bramwell, Kenneth K.C.
Teuscher, Cory
Weis, Janis J.
author_sort Bramwell, Kenneth K.C.
collection PubMed
description Patients experiencing natural infection with Borrelia burgdorferi display a spectrum of associated symptoms and severity, strongly implicating the impact of genetically determined host factors in the pathogenesis of Lyme disease. Herein, we provide a summary of the host genetic factors that have been demonstrated to influence the severity and chronicity of Lyme arthritis symptoms, and a review of the resources available, current progress, and added value of a forward genetic approach for identification of novel genetic regulators.
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spelling pubmed-40461002014-06-12 Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity Bramwell, Kenneth K.C. Teuscher, Cory Weis, Janis J. Front Cell Infect Microbiol Microbiology Patients experiencing natural infection with Borrelia burgdorferi display a spectrum of associated symptoms and severity, strongly implicating the impact of genetically determined host factors in the pathogenesis of Lyme disease. Herein, we provide a summary of the host genetic factors that have been demonstrated to influence the severity and chronicity of Lyme arthritis symptoms, and a review of the resources available, current progress, and added value of a forward genetic approach for identification of novel genetic regulators. Frontiers Media S.A. 2014-06-05 /pmc/articles/PMC4046100/ /pubmed/24926442 http://dx.doi.org/10.3389/fcimb.2014.00076 Text en Copyright © 2014 Bramwell, Teuscher and Weis. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Bramwell, Kenneth K.C.
Teuscher, Cory
Weis, Janis J.
Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity
title Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity
title_full Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity
title_fullStr Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity
title_full_unstemmed Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity
title_short Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity
title_sort forward genetic approaches for elucidation of novel regulators of lyme arthritis severity
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046100/
https://www.ncbi.nlm.nih.gov/pubmed/24926442
http://dx.doi.org/10.3389/fcimb.2014.00076
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