Bax Inhibitor-1-Mediated Inhibition of Mitochondrial Ca(2+) Intake Regulates Mitochondrial Permeability Transition Pore Opening and Cell Death

A recently studied endoplasmic reticulum (ER) stress regulator, Bax inhibitor-1 (BI-1) plays a regulatory role in mitochondrial Ca(2+) levels. In this study, we identified ER-resident and mitochondria-associated ER membrane (MAM)-resident populations of BI-1. ER stress increased mitochondrial Ca(2+)...

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Detalles Bibliográficos
Autores principales: Lee, Geum-Hwa, Lee, Hwa-Young, Li, Bo, Kim, Hyung-Ryong, Chae, Han-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046133/
https://www.ncbi.nlm.nih.gov/pubmed/24899098
http://dx.doi.org/10.1038/srep05194

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