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Nervous decision-making: to divide or differentiate

The intricate balance between proliferation and differentiation is of fundamental importance in the development of the central nervous system (CNS). The division versus differentiation decision influences both the number and identity of daughter cells produced, thus critically shaping the overall mi...

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Detalles Bibliográficos
Autores principales: Hardwick, Laura J.A., Philpott, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Trends Journals 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046230/
https://www.ncbi.nlm.nih.gov/pubmed/24791612
http://dx.doi.org/10.1016/j.tig.2014.04.001
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author Hardwick, Laura J.A.
Philpott, Anna
author_facet Hardwick, Laura J.A.
Philpott, Anna
author_sort Hardwick, Laura J.A.
collection PubMed
description The intricate balance between proliferation and differentiation is of fundamental importance in the development of the central nervous system (CNS). The division versus differentiation decision influences both the number and identity of daughter cells produced, thus critically shaping the overall microstructure and function of the CNS. During the past decade, significant advances have been made to characterise the changes in the cell cycle during differentiation, and to uncover the multiple bidirectional links that coordinate these two processes. Here, we explore the nature and mechanistic basis of these links in the context of the developing CNS, highlighting new insights into transcriptional, post-translational, and epigenetic levels of interaction.
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spelling pubmed-40462302014-06-06 Nervous decision-making: to divide or differentiate Hardwick, Laura J.A. Philpott, Anna Trends Genet Review The intricate balance between proliferation and differentiation is of fundamental importance in the development of the central nervous system (CNS). The division versus differentiation decision influences both the number and identity of daughter cells produced, thus critically shaping the overall microstructure and function of the CNS. During the past decade, significant advances have been made to characterise the changes in the cell cycle during differentiation, and to uncover the multiple bidirectional links that coordinate these two processes. Here, we explore the nature and mechanistic basis of these links in the context of the developing CNS, highlighting new insights into transcriptional, post-translational, and epigenetic levels of interaction. Elsevier Trends Journals 2014-06 /pmc/articles/PMC4046230/ /pubmed/24791612 http://dx.doi.org/10.1016/j.tig.2014.04.001 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Hardwick, Laura J.A.
Philpott, Anna
Nervous decision-making: to divide or differentiate
title Nervous decision-making: to divide or differentiate
title_full Nervous decision-making: to divide or differentiate
title_fullStr Nervous decision-making: to divide or differentiate
title_full_unstemmed Nervous decision-making: to divide or differentiate
title_short Nervous decision-making: to divide or differentiate
title_sort nervous decision-making: to divide or differentiate
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046230/
https://www.ncbi.nlm.nih.gov/pubmed/24791612
http://dx.doi.org/10.1016/j.tig.2014.04.001
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