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Disrupted resting-state functional architecture of the brain after 45-day simulated microgravity
Long-term spaceflight induces both physiological and psychological changes in astronauts. To understand the neural mechanisms underlying these physiological and psychological changes, it is critical to investigate the effects of microgravity on the functional architecture of the brain. In this study...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046318/ https://www.ncbi.nlm.nih.gov/pubmed/24926242 http://dx.doi.org/10.3389/fnbeh.2014.00200 |
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author | Zhou, Yuan Wang, Yun Rao, Li-Lin Liang, Zhu-Yuan Chen, Xiao-Ping Zheng, Dang Tan, Cheng Tian, Zhi-Qiang Wang, Chun-Hui Bai, Yan-Qiang Chen, Shan-Guang Li, Shu |
author_facet | Zhou, Yuan Wang, Yun Rao, Li-Lin Liang, Zhu-Yuan Chen, Xiao-Ping Zheng, Dang Tan, Cheng Tian, Zhi-Qiang Wang, Chun-Hui Bai, Yan-Qiang Chen, Shan-Guang Li, Shu |
author_sort | Zhou, Yuan |
collection | PubMed |
description | Long-term spaceflight induces both physiological and psychological changes in astronauts. To understand the neural mechanisms underlying these physiological and psychological changes, it is critical to investigate the effects of microgravity on the functional architecture of the brain. In this study, we used resting-state functional MRI (rs-fMRI) to study whether the functional architecture of the brain is altered after 45 days of −6° head-down tilt (HDT) bed rest, which is a reliable model for the simulation of microgravity. Sixteen healthy male volunteers underwent rs-fMRI scans before and after 45 days of −6° HDT bed rest. Specifically, we used a commonly employed graph-based measure of network organization, i.e., degree centrality (DC), to perform a full-brain exploration of the regions that were influenced by simulated microgravity. We subsequently examined the functional connectivities of these regions using a seed-based resting-state functional connectivity (RSFC) analysis. We found decreased DC in two regions, the left anterior insula (aINS) and the anterior part of the middle cingulate cortex (MCC; also called the dorsal anterior cingulate cortex in many studies), in the male volunteers after 45 days of −6° HDT bed rest. Furthermore, seed-based RSFC analyses revealed that a functional network anchored in the aINS and MCC was particularly influenced by simulated microgravity. These results provide evidence that simulated microgravity alters the resting-state functional architecture of the brains of males and suggest that the processing of salience information, which is primarily subserved by the aINS–MCC functional network, is particularly influenced by spaceflight. The current findings provide a new perspective for understanding the relationships between microgravity, cognitive function, autonomic neural function, and central neural activity. |
format | Online Article Text |
id | pubmed-4046318 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-40463182014-06-12 Disrupted resting-state functional architecture of the brain after 45-day simulated microgravity Zhou, Yuan Wang, Yun Rao, Li-Lin Liang, Zhu-Yuan Chen, Xiao-Ping Zheng, Dang Tan, Cheng Tian, Zhi-Qiang Wang, Chun-Hui Bai, Yan-Qiang Chen, Shan-Guang Li, Shu Front Behav Neurosci Neuroscience Long-term spaceflight induces both physiological and psychological changes in astronauts. To understand the neural mechanisms underlying these physiological and psychological changes, it is critical to investigate the effects of microgravity on the functional architecture of the brain. In this study, we used resting-state functional MRI (rs-fMRI) to study whether the functional architecture of the brain is altered after 45 days of −6° head-down tilt (HDT) bed rest, which is a reliable model for the simulation of microgravity. Sixteen healthy male volunteers underwent rs-fMRI scans before and after 45 days of −6° HDT bed rest. Specifically, we used a commonly employed graph-based measure of network organization, i.e., degree centrality (DC), to perform a full-brain exploration of the regions that were influenced by simulated microgravity. We subsequently examined the functional connectivities of these regions using a seed-based resting-state functional connectivity (RSFC) analysis. We found decreased DC in two regions, the left anterior insula (aINS) and the anterior part of the middle cingulate cortex (MCC; also called the dorsal anterior cingulate cortex in many studies), in the male volunteers after 45 days of −6° HDT bed rest. Furthermore, seed-based RSFC analyses revealed that a functional network anchored in the aINS and MCC was particularly influenced by simulated microgravity. These results provide evidence that simulated microgravity alters the resting-state functional architecture of the brains of males and suggest that the processing of salience information, which is primarily subserved by the aINS–MCC functional network, is particularly influenced by spaceflight. The current findings provide a new perspective for understanding the relationships between microgravity, cognitive function, autonomic neural function, and central neural activity. Frontiers Media S.A. 2014-06-05 /pmc/articles/PMC4046318/ /pubmed/24926242 http://dx.doi.org/10.3389/fnbeh.2014.00200 Text en Copyright © 2014 Zhou, Wang, Rao, Liang, Chen, Zheng, Tan, Tian, Wang, Bai, Chen and Li. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhou, Yuan Wang, Yun Rao, Li-Lin Liang, Zhu-Yuan Chen, Xiao-Ping Zheng, Dang Tan, Cheng Tian, Zhi-Qiang Wang, Chun-Hui Bai, Yan-Qiang Chen, Shan-Guang Li, Shu Disrupted resting-state functional architecture of the brain after 45-day simulated microgravity |
title | Disrupted resting-state functional architecture of the brain after 45-day simulated microgravity |
title_full | Disrupted resting-state functional architecture of the brain after 45-day simulated microgravity |
title_fullStr | Disrupted resting-state functional architecture of the brain after 45-day simulated microgravity |
title_full_unstemmed | Disrupted resting-state functional architecture of the brain after 45-day simulated microgravity |
title_short | Disrupted resting-state functional architecture of the brain after 45-day simulated microgravity |
title_sort | disrupted resting-state functional architecture of the brain after 45-day simulated microgravity |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046318/ https://www.ncbi.nlm.nih.gov/pubmed/24926242 http://dx.doi.org/10.3389/fnbeh.2014.00200 |
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