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Molecular chaperones and protein folding as therapeutic targets in Parkinson’s disease and other synucleinopathies
Changes in protein metabolism are key to disease onset and progression in many neurodegenerative diseases. As a prime example, in Parkinson’s disease, folding, post-translational modification and recycling of the synaptic protein α-synuclein are clearly altered, leading to a progressive accumulation...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046681/ https://www.ncbi.nlm.nih.gov/pubmed/24314025 http://dx.doi.org/10.1186/2051-5960-1-79 |