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Rational Design and Bioimaging Applications of Highly Selective Fluorescence Probes for Hydrogen Polysulfides

[Image: see text] Reactive sulfur species have received considerable attention due to their various biological functions. Among these molecules, hydrogen polysulfides (H(2)S(n), n > 1) are recently suggested to be the actual signaling molecules derived from hydrogen sulfide (H(2)S). Hydrogen poly...

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Autores principales: Liu, Chunrong, Chen, Wei, Shi, Wen, Peng, Bo, Zhao, Yu, Ma, Huimin, Xian, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046760/
https://www.ncbi.nlm.nih.gov/pubmed/24809803
http://dx.doi.org/10.1021/ja502968x
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author Liu, Chunrong
Chen, Wei
Shi, Wen
Peng, Bo
Zhao, Yu
Ma, Huimin
Xian, Ming
author_facet Liu, Chunrong
Chen, Wei
Shi, Wen
Peng, Bo
Zhao, Yu
Ma, Huimin
Xian, Ming
author_sort Liu, Chunrong
collection PubMed
description [Image: see text] Reactive sulfur species have received considerable attention due to their various biological functions. Among these molecules, hydrogen polysulfides (H(2)S(n), n > 1) are recently suggested to be the actual signaling molecules derived from hydrogen sulfide (H(2)S). Hydrogen polysulfides may also have their own biosynthetic pathways. The research on H(2)S(n) is rapidly growing. However, the detection of H(2)S(n) is still challenging. In this work we report a H(2)S(n)-mediated benzodithiolone formation under mild conditions. Based on this reaction, specific fluorescent probes for H(2)S(n) are prepared and evaluated. The probe DSP-3 shows good selectivity and sensitivity for H(2)S(n).
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spelling pubmed-40467602015-05-08 Rational Design and Bioimaging Applications of Highly Selective Fluorescence Probes for Hydrogen Polysulfides Liu, Chunrong Chen, Wei Shi, Wen Peng, Bo Zhao, Yu Ma, Huimin Xian, Ming J Am Chem Soc [Image: see text] Reactive sulfur species have received considerable attention due to their various biological functions. Among these molecules, hydrogen polysulfides (H(2)S(n), n > 1) are recently suggested to be the actual signaling molecules derived from hydrogen sulfide (H(2)S). Hydrogen polysulfides may also have their own biosynthetic pathways. The research on H(2)S(n) is rapidly growing. However, the detection of H(2)S(n) is still challenging. In this work we report a H(2)S(n)-mediated benzodithiolone formation under mild conditions. Based on this reaction, specific fluorescent probes for H(2)S(n) are prepared and evaluated. The probe DSP-3 shows good selectivity and sensitivity for H(2)S(n). American Chemical Society 2014-05-08 2014-05-21 /pmc/articles/PMC4046760/ /pubmed/24809803 http://dx.doi.org/10.1021/ja502968x Text en Copyright © 2014 American Chemical Society
spellingShingle Liu, Chunrong
Chen, Wei
Shi, Wen
Peng, Bo
Zhao, Yu
Ma, Huimin
Xian, Ming
Rational Design and Bioimaging Applications of Highly Selective Fluorescence Probes for Hydrogen Polysulfides
title Rational Design and Bioimaging Applications of Highly Selective Fluorescence Probes for Hydrogen Polysulfides
title_full Rational Design and Bioimaging Applications of Highly Selective Fluorescence Probes for Hydrogen Polysulfides
title_fullStr Rational Design and Bioimaging Applications of Highly Selective Fluorescence Probes for Hydrogen Polysulfides
title_full_unstemmed Rational Design and Bioimaging Applications of Highly Selective Fluorescence Probes for Hydrogen Polysulfides
title_short Rational Design and Bioimaging Applications of Highly Selective Fluorescence Probes for Hydrogen Polysulfides
title_sort rational design and bioimaging applications of highly selective fluorescence probes for hydrogen polysulfides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046760/
https://www.ncbi.nlm.nih.gov/pubmed/24809803
http://dx.doi.org/10.1021/ja502968x
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