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Substrate Deconstruction and the Nonadditivity of Enzyme Recognition
[Image: see text] Predicting substrates for enzymes of unknown function is a major postgenomic challenge. Substrate discovery, like inhibitor discovery, is constrained by our ability to explore chemotypes; it would be expanded by orders of magnitude if reactive sites could be probed with fragments r...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046767/ https://www.ncbi.nlm.nih.gov/pubmed/24791931 http://dx.doi.org/10.1021/ja501354q |