Cargando…

The type of Aβ-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid β-peptide (APP48) transgenic mice

BACKGROUND: The deposition of the amyloid β-peptide (Aβ) in the brain is one of the hallmarks of Alzheimer’s disease (AD). It is not yet clear whether Aβ always leads to similar changes or whether it induces different features of neurodegeneration in relation to its intra- and/or extracellular local...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rijal Upadhaya, Ajeet, Scheibe, Frederik, Kosterin, Irina, Abramowski, Dorothee, Gerth, Janina, Kumar, Sathish, Liebau, Stefan, Yamaguchi, Haruyasu, Walter, Jochen, Staufenbiel, Matthias, Thal, Dietmar Rudolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046770/ https://www.ncbi.nlm.nih.gov/pubmed/24252227 http://dx.doi.org/10.1186/2051-5960-1-77

Ejemplares similares

Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice
por: Balakrishnan, Karthikeyan, et al.
Publicado: (2015)

Modified amyloid variants in pathological subgroups of β‐amyloidosis
por: Gerth, Janina, et al.
Publicado: (2018)

High-molecular weight Aβ oligomers and protofibrils are the predominant Aβ species in the native soluble protein fraction of the AD brain
por: Upadhaya, Ajeet Rijal, et al.
Publicado: (2012)

β-Amyloid precursor protein (APP) and the human diseases
por: Nguyen, Khue Vu
Publicado: (2019)

EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-β Production
por: Nowakowska-Gołacka, Jowita, et al.
Publicado: (2021)

Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin β
por: Menon, Preeti Kumaran, et al.
Publicado: (2019)

Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia
por: Thal, Dietmar Rudolf, et al.
Publicado: (2019)

Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer’s disease and normal physiology
por: Pfundstein, Grant, et al.
Publicado: (2022)

Amyloid Precursor Protein (APP) and GABAergic Neurotransmission
por: Tang, Bor Luen
Publicado: (2019)

Transcriptional and Post-Transcriptional Regulations of Amyloid-β Precursor Protein (APP) mRNA
por: Sato, Kaoru, et al.
Publicado: (2021)

Correction to: Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia
por: Thal, Dietmar Rudolf, et al.
Publicado: (2020)

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
por: Zhang, Xiaojie, et al.
Publicado: (2013)

Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype
por: Whitehouse, Isobel J., et al.
Publicado: (2016)

Multiplex Assay for Live-Cell Monitoring of Cellular Fates of Amyloid-β Precursor Protein (APP)
por: Merezhko, Maria, et al.
Publicado: (2014)

O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP)
por: Jacobsen, Kristin, et al.
Publicado: (2013)

Intracellular Trafficking of the Amyloid β-Protein Precursor (APP) Regulated by Novel Function of X11-Like
por: Saito, Yuhki, et al.
Publicado: (2011)

Role of amyloid precursor protein (APP) in regulation of neuronal genes
por: Nalivaeva, Natalia N.
Publicado: (2015)

Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα
por: Mockett, Bruce G., et al.
Publicado: (2017)

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice
por: Steffen, Johannes, et al.
Publicado: (2017)

The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)
por: von Einem, Bjoern, et al.
Publicado: (2015)

Accumulation of amyloid beta (Aβ) and amyloid precursor protein (APP) in tumors formed by a mouse xenograft model of inflammatory breast cancer
por: Zayas‐Santiago, Astrid, et al.
Publicado: (2021)

Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells
por: Ristori, Emma, et al.
Publicado: (2020)

Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression
por: Ruiz-Riquelme, Alejandro, et al.
Publicado: (2018)

Clearance of amyloid β-protein and its role in the spreading of Alzheimer's disease pathology
por: Thal, Dietmar R.
Publicado: (2015)

The Alzheimer Amyloid Precursor Protein (APP) and Fe65, an APP-Binding Protein, Regulate Cell Movement
por: Sabo, Shasta L., et al.
Publicado: (2001)

Analysis of the Overall Structure of the Multi-Domain Amyloid Precursor Protein (APP)
por: Coburger, Ina, et al.
Publicado: (2013)

Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer
por: Lee, Han Na, et al.
Publicado: (2021)

MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties
por: Chopra, Nipun, et al.
Publicado: (2020)

Expression of complement system components during aging and amyloid deposition in APP transgenic mice
por: Reichwald, Julia, et al.
Publicado: (2009)

α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP
por: Roberts, Hazel L., et al.
Publicado: (2017)

APP intracellular domain/WAVE1 pathway reduces amyloid β production
por: Ceglia, Ilaria, et al.
Publicado: (2015)

Neuronal Rubicon Represses Extracellular APP/Amyloid β Deposition in Alzheimer’s Disease
por: Espinoza, Sandra, et al.
Publicado: (2022)

Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease
por: Long, Justin M., et al.
Publicado: (2018)

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation
por: Maesako, Masato, et al.
Publicado: (2015)

Justicidin A Reduces β-Amyloid via Inhibiting Endocytosis of β-Amyloid Precursor Protein
por: Chun, Yoon Sun, et al.
Publicado: (2019)

Heterogeneous Association of Alzheimer’s Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses
por: Willén, Katarina, et al.
Publicado: (2017)

Amyloid, APP, and Electrical Activity of the Brain
por: Hefter, Dimitri, et al.
Publicado: (2019)

A lipid boundary separates APP and secretases and limits amyloid β-peptide generation
por: Kaether, Christoph, et al.
Publicado: (2004)

A role for APP in Wnt signalling links synapse loss with β-amyloid production
por: Elliott, Christina, et al.
Publicado: (2018)

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model
por: Rice, Heather C., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6ks5gc9puvd6avk77mpfja6edr