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Genetic Background Drives Transcriptional Variation in Human Induced Pluripotent Stem Cells
Human iPS cells have been generated using a diverse range of tissues from a variety of donors using different reprogramming vectors. However, these cell lines are heterogeneous, which presents a limitation for their use in disease modeling and personalized medicine. To explore the basis of this hete...
Autores principales: | Rouhani, Foad, Kumasaka, Natsuhiko, de Brito, Miguel Cardoso, Bradley, Allan, Vallier, Ludovic, Gaffney, Daniel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046971/ https://www.ncbi.nlm.nih.gov/pubmed/24901476 http://dx.doi.org/10.1371/journal.pgen.1004432 |
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