Cargando…

Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of UGT1A1*28 Polymorphism in Young Obese

OBJECTIVES: Bilirubin has potential antioxidant and anti-inflammatory properties. The UGT1A1*28 polymorphism (TA repeats in the promoter region) is a major determinant of bilirubin levels and recent evidence suggests that raised adiposity may also be a contributing factor. We aimed to study the inte...

Descripción completa

Detalles Bibliográficos
Autores principales: Belo, Luís, Nascimento, Henrique, Kohlova, Michaela, Bronze-da-Rocha, Elsa, Fernandes, João, Costa, Elísio, Catarino, Cristina, Aires, Luísa, Mansilha, Helena Ferreira, Rocha-Pereira, Petronila, Quintanilha, Alexandre, Rêgo, Carla, Santos-Silva, Alice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046990/
https://www.ncbi.nlm.nih.gov/pubmed/24901842
http://dx.doi.org/10.1371/journal.pone.0098467
_version_ 1782480343723409408
author Belo, Luís
Nascimento, Henrique
Kohlova, Michaela
Bronze-da-Rocha, Elsa
Fernandes, João
Costa, Elísio
Catarino, Cristina
Aires, Luísa
Mansilha, Helena Ferreira
Rocha-Pereira, Petronila
Quintanilha, Alexandre
Rêgo, Carla
Santos-Silva, Alice
author_facet Belo, Luís
Nascimento, Henrique
Kohlova, Michaela
Bronze-da-Rocha, Elsa
Fernandes, João
Costa, Elísio
Catarino, Cristina
Aires, Luísa
Mansilha, Helena Ferreira
Rocha-Pereira, Petronila
Quintanilha, Alexandre
Rêgo, Carla
Santos-Silva, Alice
author_sort Belo, Luís
collection PubMed
description OBJECTIVES: Bilirubin has potential antioxidant and anti-inflammatory properties. The UGT1A1*28 polymorphism (TA repeats in the promoter region) is a major determinant of bilirubin levels and recent evidence suggests that raised adiposity may also be a contributing factor. We aimed to study the interaction between UGT1A1 polymorphism, hematological and anthropometric variables with total bilirubin levels in young individuals. METHODS: 350 obese (mean age of 11.6 years; 52% females) and 79 controls (mean age of 10.5 years; 59% females) were included. Total bilirubin and C-reactive protein (CRP) plasma levels, hemogram, anthropometric data and UGT1A1 polymorphism were determined. In a subgroup of 74 obese and 40 controls body composition was analyzed by dual-energy X-ray absorptiometry. RESULTS: The UGT1A1 genotype frequencies were 49.9%, 42.7% and 7.5% for 6/6, 6/7 and 7/7 genotypes, respectively. Patients with 7/7 genotype presented the highest total bilirubin levels, followed by 6/7 and 6/6 genotypes. Compared to controls, obese patients presented higher erythrocyte count, hematocrit, hemoglobin and CRP levels, but no differences in bilirubin or in UGT1A1 genotype distribution. Body fat percentage was inversely correlated with bilirubin in obese patients but not in controls. This inverse association was observed either in 6/7 or 6/6 genotype obese patients. UGT1A1 polymorphism and body fat percentage were the main factors affecting bilirubin levels within obese patients (linear regression analysis). CONCLUSION: In obese children and adolescents, body fat composition and UGT1A1 polymorphism are independent determinants of total bilirubin levels. Obese individuals with 6/6 UGT1A1 genotype and higher body fat mass may benefit from a closer clinical follow-up.
format Online
Article
Text
id pubmed-4046990
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-40469902014-06-09 Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of UGT1A1*28 Polymorphism in Young Obese Belo, Luís Nascimento, Henrique Kohlova, Michaela Bronze-da-Rocha, Elsa Fernandes, João Costa, Elísio Catarino, Cristina Aires, Luísa Mansilha, Helena Ferreira Rocha-Pereira, Petronila Quintanilha, Alexandre Rêgo, Carla Santos-Silva, Alice PLoS One Research Article OBJECTIVES: Bilirubin has potential antioxidant and anti-inflammatory properties. The UGT1A1*28 polymorphism (TA repeats in the promoter region) is a major determinant of bilirubin levels and recent evidence suggests that raised adiposity may also be a contributing factor. We aimed to study the interaction between UGT1A1 polymorphism, hematological and anthropometric variables with total bilirubin levels in young individuals. METHODS: 350 obese (mean age of 11.6 years; 52% females) and 79 controls (mean age of 10.5 years; 59% females) were included. Total bilirubin and C-reactive protein (CRP) plasma levels, hemogram, anthropometric data and UGT1A1 polymorphism were determined. In a subgroup of 74 obese and 40 controls body composition was analyzed by dual-energy X-ray absorptiometry. RESULTS: The UGT1A1 genotype frequencies were 49.9%, 42.7% and 7.5% for 6/6, 6/7 and 7/7 genotypes, respectively. Patients with 7/7 genotype presented the highest total bilirubin levels, followed by 6/7 and 6/6 genotypes. Compared to controls, obese patients presented higher erythrocyte count, hematocrit, hemoglobin and CRP levels, but no differences in bilirubin or in UGT1A1 genotype distribution. Body fat percentage was inversely correlated with bilirubin in obese patients but not in controls. This inverse association was observed either in 6/7 or 6/6 genotype obese patients. UGT1A1 polymorphism and body fat percentage were the main factors affecting bilirubin levels within obese patients (linear regression analysis). CONCLUSION: In obese children and adolescents, body fat composition and UGT1A1 polymorphism are independent determinants of total bilirubin levels. Obese individuals with 6/6 UGT1A1 genotype and higher body fat mass may benefit from a closer clinical follow-up. Public Library of Science 2014-06-05 /pmc/articles/PMC4046990/ /pubmed/24901842 http://dx.doi.org/10.1371/journal.pone.0098467 Text en © 2014 Belo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Belo, Luís
Nascimento, Henrique
Kohlova, Michaela
Bronze-da-Rocha, Elsa
Fernandes, João
Costa, Elísio
Catarino, Cristina
Aires, Luísa
Mansilha, Helena Ferreira
Rocha-Pereira, Petronila
Quintanilha, Alexandre
Rêgo, Carla
Santos-Silva, Alice
Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of UGT1A1*28 Polymorphism in Young Obese
title Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of UGT1A1*28 Polymorphism in Young Obese
title_full Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of UGT1A1*28 Polymorphism in Young Obese
title_fullStr Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of UGT1A1*28 Polymorphism in Young Obese
title_full_unstemmed Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of UGT1A1*28 Polymorphism in Young Obese
title_short Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of UGT1A1*28 Polymorphism in Young Obese
title_sort body fat percentage is a major determinant of total bilirubin independently of ugt1a1*28 polymorphism in young obese
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046990/
https://www.ncbi.nlm.nih.gov/pubmed/24901842
http://dx.doi.org/10.1371/journal.pone.0098467
work_keys_str_mv AT beloluis bodyfatpercentageisamajordeterminantoftotalbilirubinindependentlyofugt1a128polymorphisminyoungobese
AT nascimentohenrique bodyfatpercentageisamajordeterminantoftotalbilirubinindependentlyofugt1a128polymorphisminyoungobese
AT kohlovamichaela bodyfatpercentageisamajordeterminantoftotalbilirubinindependentlyofugt1a128polymorphisminyoungobese
AT bronzedarochaelsa bodyfatpercentageisamajordeterminantoftotalbilirubinindependentlyofugt1a128polymorphisminyoungobese
AT fernandesjoao bodyfatpercentageisamajordeterminantoftotalbilirubinindependentlyofugt1a128polymorphisminyoungobese
AT costaelisio bodyfatpercentageisamajordeterminantoftotalbilirubinindependentlyofugt1a128polymorphisminyoungobese
AT catarinocristina bodyfatpercentageisamajordeterminantoftotalbilirubinindependentlyofugt1a128polymorphisminyoungobese
AT airesluisa bodyfatpercentageisamajordeterminantoftotalbilirubinindependentlyofugt1a128polymorphisminyoungobese
AT mansilhahelenaferreira bodyfatpercentageisamajordeterminantoftotalbilirubinindependentlyofugt1a128polymorphisminyoungobese
AT rochapereirapetronila bodyfatpercentageisamajordeterminantoftotalbilirubinindependentlyofugt1a128polymorphisminyoungobese
AT quintanilhaalexandre bodyfatpercentageisamajordeterminantoftotalbilirubinindependentlyofugt1a128polymorphisminyoungobese
AT regocarla bodyfatpercentageisamajordeterminantoftotalbilirubinindependentlyofugt1a128polymorphisminyoungobese
AT santossilvaalice bodyfatpercentageisamajordeterminantoftotalbilirubinindependentlyofugt1a128polymorphisminyoungobese