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Sinomenine Sensitizes Multidrug-Resistant Colon Cancer Cells (Caco-2) to Doxorubicin by Downregulation of MDR-1 Expression

Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotein (P-gp) encoded by the MDR1 gene, is a major obstacle to successful chemotherapy for colorectal cancer. Previous studies have indicated that sinomenine can enhance the absorption of various P-gp substrates. In the prese...

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Detalles Bibliográficos
Autores principales:	Liu, Zhen, Duan, Zhi-Jun, Chang, Jiu-Yang, Zhang, Zhi-feng, Chu, Rui, Li, Yu-Ling, Dai, Ke-Hang, Mo, Guang-quan, Chang, Qing-Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047020/ https://www.ncbi.nlm.nih.gov/pubmed/24901713 http://dx.doi.org/10.1371/journal.pone.0098560

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