A High Through-Put Screen for Small Molecules Modulating MCM2 Phosphorylation Identifies Ryuvidine as an Inducer of the DNA Damage Response

DNA replication is an essential process for cell division and as such it is a process that is directly targeted by several anticancer drugs. CDC7 plays an essential role in the activation of replication origins and has recently been proposed as a novel target for drug discovery. The MCM DNA helicase...

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Detalles Bibliográficos
Autores principales: FitzGerald, Jennifer, Murillo, Laura S., O'Brien, Gemma, O'Connell, Enda, O'Connor, Aisling, Wu, Kevin, Wang, Guan-Nan, Rainey, Michael D., Natoni, Alessandro, Healy, Sandra, O'Dwyer, Michael, Santocanale, Corrado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047068/
https://www.ncbi.nlm.nih.gov/pubmed/24902048
http://dx.doi.org/10.1371/journal.pone.0098891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047068/
https://www.ncbi.nlm.nih.gov/pubmed/24902048
http://dx.doi.org/10.1371/journal.pone.0098891

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