ChR2 Mutants at L132 and T159 with Improved Operational Light Sensitivity for Vision Restoration

The ectopic expression of microbial opsin-based optogenetic sensors, such as channelrhodopsin-2 (ChR2) in surviving inner retinal neurons, is a promising approach to restoring vision after retinal degeneration. However, a major limitation in using native ChR2 as a light sensor for vision restoration...

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Detalles Bibliográficos
Autores principales: Pan, Zhuo-Hua, Ganjawala, Tushar H., Lu, Qi, Ivanova, Elena, Zhang, Zhifei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047080/
https://www.ncbi.nlm.nih.gov/pubmed/24901492
http://dx.doi.org/10.1371/journal.pone.0098924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047080/
https://www.ncbi.nlm.nih.gov/pubmed/24901492
http://dx.doi.org/10.1371/journal.pone.0098924

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