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ChR2 Mutants at L132 and T159 with Improved Operational Light Sensitivity for Vision Restoration
The ectopic expression of microbial opsin-based optogenetic sensors, such as channelrhodopsin-2 (ChR2) in surviving inner retinal neurons, is a promising approach to restoring vision after retinal degeneration. However, a major limitation in using native ChR2 as a light sensor for vision restoration...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047080/ https://www.ncbi.nlm.nih.gov/pubmed/24901492 http://dx.doi.org/10.1371/journal.pone.0098924 |