Mutation of Serine 1333 in the ATR HEAT Repeats Creates a Hyperactive Kinase

Subcellular localization, protein interactions, and post-translational modifications regulate the DNA damage response kinases ATR, ATM, and DNA-PK. During an analysis of putative ATR phosphorylation sites, we found that a single mutation at S1333 creates a hyperactive kinase. In vitro and in cells,...

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Detalles Bibliográficos
Autores principales: Luzwick, Jessica W., Nam, Edward A., Zhao, Runxiang, Cortez, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047089/
https://www.ncbi.nlm.nih.gov/pubmed/24901225
http://dx.doi.org/10.1371/journal.pone.0099397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047089/
https://www.ncbi.nlm.nih.gov/pubmed/24901225
http://dx.doi.org/10.1371/journal.pone.0099397

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