Cargando…
Mutation of Serine 1333 in the ATR HEAT Repeats Creates a Hyperactive Kinase
Subcellular localization, protein interactions, and post-translational modifications regulate the DNA damage response kinases ATR, ATM, and DNA-PK. During an analysis of putative ATR phosphorylation sites, we found that a single mutation at S1333 creates a hyperactive kinase. In vitro and in cells,...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047089/ https://www.ncbi.nlm.nih.gov/pubmed/24901225 http://dx.doi.org/10.1371/journal.pone.0099397 |