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Mutation of Serine 1333 in the ATR HEAT Repeats Creates a Hyperactive Kinase
Subcellular localization, protein interactions, and post-translational modifications regulate the DNA damage response kinases ATR, ATM, and DNA-PK. During an analysis of putative ATR phosphorylation sites, we found that a single mutation at S1333 creates a hyperactive kinase. In vitro and in cells,...
Autores principales: | Luzwick, Jessica W., Nam, Edward A., Zhao, Runxiang, Cortez, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047089/ https://www.ncbi.nlm.nih.gov/pubmed/24901225 http://dx.doi.org/10.1371/journal.pone.0099397 |
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