Disruption of Interleukin-1β Autocrine Signaling Rescues Complex I Activity and Improves ROS Levels in Immortalized Epithelial Cells with Impaired Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function

Patients with cystic fibrosis (CF) have elevated concentration of cytokines in sputum and a general inflammatory condition. In addition, CF cells in culture produce diverse cytokines in excess, including IL-1β. We have previously shown that IL-1β, at low doses (∼30 pM), can stimulate the expression...

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Detalles Bibliográficos
Autores principales: Clauzure, Mariángeles, Valdivieso, Angel G., Massip Copiz, María M., Schulman, Gustavo, Teiber, María Luz, Santa-Coloma, Tomás A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047112/
https://www.ncbi.nlm.nih.gov/pubmed/24901709
http://dx.doi.org/10.1371/journal.pone.0099257

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