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Family studies of Type 1 diabetes reveal additive and epistatic effects between MGAT1 and three other polymorphisms

In a recent study of Multiple Sclerosis (MS), we observed additive effects and epistatic interactions between variants of four genes that converge to induce T cell hyper-activity by altering Asn-(N) linked protein glycosylation: namely, the Golgi enzyme MGAT1, cytotoxic T-lymphocyte antigen 4 (CTLA-...

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Detalles Bibliográficos
Autores principales:	Yu, Zhaoxia, Li, Carey F., Mkhikian, Haik, Zhou, Raymond W., Newton, Barbara L., Demetriou, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047175/ https://www.ncbi.nlm.nih.gov/pubmed/24572742 http://dx.doi.org/10.1038/gene.2014.7

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