The effect of the sympathetic nervous system on splenic natural killer cell activity in mice administered the Lactobacillus pentosus strain S-PT84

Splenic sympathetic nerve activity (SNA) modulates cellular immune functions such as splenic natural killer cell activity. Lactobacillus pentosus strain S-PT84 enhances splenic natural killer cell activity. Here, we examined whether S-PT84 affects splenic natural killer activity through splenic SNA...

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Autores principales: Izumo, Takayuki, Maekawa, Toshihiro, Horii, Yuko, Fujisaki, Yoshiyuki, Ida, Masayuki, Furukawa, Yuichi, Ono, Yoshiko, Kiso, Yoshinobu, Kitagawa, Yoshinori, Shibata, Hiroshi, Nagai, Katsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2013
Materias:
Immune System
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047316/
https://www.ncbi.nlm.nih.gov/pubmed/24165047
http://dx.doi.org/10.1097/WNR.0000000000000036
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author Izumo, Takayuki
Maekawa, Toshihiro
Horii, Yuko
Fujisaki, Yoshiyuki
Ida, Masayuki
Furukawa, Yuichi
Ono, Yoshiko
Kiso, Yoshinobu
Kitagawa, Yoshinori
Shibata, Hiroshi
Nagai, Katsuya
author_facet Izumo, Takayuki
Maekawa, Toshihiro
Horii, Yuko
Fujisaki, Yoshiyuki
Ida, Masayuki
Furukawa, Yuichi
Ono, Yoshiko
Kiso, Yoshinobu
Kitagawa, Yoshinori
Shibata, Hiroshi
Nagai, Katsuya
author_sort Izumo, Takayuki
collection PubMed
description Splenic sympathetic nerve activity (SNA) modulates cellular immune functions such as splenic natural killer cell activity. Lactobacillus pentosus strain S-PT84 enhances splenic natural killer cell activity. Here, we examined whether S-PT84 affects splenic natural killer activity through splenic SNA in BALB/c mice. Splenic SNA was significantly decreased following the administration of S-PT84. This phenomenon was inhibited by pretreatment with thioperamide (histamine H(3) receptor antagonist), suggesting that S-PT84 directly affected splenic SNA. Thioperamide also inhibited the increase in splenic natural killer activity by S-PT84. Thus, the change in splenic natural killer activity by S-PT84 may be partially modulated through SNA.
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spelling pubmed-40473162014-06-06 The effect of the sympathetic nervous system on splenic natural killer cell activity in mice administered the Lactobacillus pentosus strain S-PT84 Izumo, Takayuki Maekawa, Toshihiro Horii, Yuko Fujisaki, Yoshiyuki Ida, Masayuki Furukawa, Yuichi Ono, Yoshiko Kiso, Yoshinobu Kitagawa, Yoshinori Shibata, Hiroshi Nagai, Katsuya Neuroreport Immune System Splenic sympathetic nerve activity (SNA) modulates cellular immune functions such as splenic natural killer cell activity. Lactobacillus pentosus strain S-PT84 enhances splenic natural killer cell activity. Here, we examined whether S-PT84 affects splenic natural killer activity through splenic SNA in BALB/c mice. Splenic SNA was significantly decreased following the administration of S-PT84. This phenomenon was inhibited by pretreatment with thioperamide (histamine H(3) receptor antagonist), suggesting that S-PT84 directly affected splenic SNA. Thioperamide also inhibited the increase in splenic natural killer activity by S-PT84. Thus, the change in splenic natural killer activity by S-PT84 may be partially modulated through SNA. Lippincott Williams & Wilkins 2013-12-04 2013-10-28 /pmc/articles/PMC4047316/ /pubmed/24165047 http://dx.doi.org/10.1097/WNR.0000000000000036 Text en © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins http://creativecommons.org/licenses/by-nc-nd/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially http://creativecommons.org/licenses/by-nc-nd/3.0.
spellingShingle Immune System
Izumo, Takayuki
Maekawa, Toshihiro
Horii, Yuko
Fujisaki, Yoshiyuki
Ida, Masayuki
Furukawa, Yuichi
Ono, Yoshiko
Kiso, Yoshinobu
Kitagawa, Yoshinori
Shibata, Hiroshi
Nagai, Katsuya
The effect of the sympathetic nervous system on splenic natural killer cell activity in mice administered the Lactobacillus pentosus strain S-PT84
title The effect of the sympathetic nervous system on splenic natural killer cell activity in mice administered the Lactobacillus pentosus strain S-PT84
title_full The effect of the sympathetic nervous system on splenic natural killer cell activity in mice administered the Lactobacillus pentosus strain S-PT84
title_fullStr The effect of the sympathetic nervous system on splenic natural killer cell activity in mice administered the Lactobacillus pentosus strain S-PT84
title_full_unstemmed The effect of the sympathetic nervous system on splenic natural killer cell activity in mice administered the Lactobacillus pentosus strain S-PT84
title_short The effect of the sympathetic nervous system on splenic natural killer cell activity in mice administered the Lactobacillus pentosus strain S-PT84
title_sort effect of the sympathetic nervous system on splenic natural killer cell activity in mice administered the lactobacillus pentosus strain s-pt84
topic Immune System
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047316/
https://www.ncbi.nlm.nih.gov/pubmed/24165047
http://dx.doi.org/10.1097/WNR.0000000000000036
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