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The use of psychiatric drugs and worsening body mass index among inpatients with schizophrenia

The aim of the present study was to investigate the relationship between 10 psychotropic agents and worsening BMI from overweight to obesity among inpatients with schizophrenia. A total of 138 patients with schizophrenia were recruited in this retrospective study. We included 23 patients with worsen...

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Autores principales: Wang, Po-Sheng, Wu, Shang-Liang, Ching, Han-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams And Wilkins 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047318/
https://www.ncbi.nlm.nih.gov/pubmed/24398897
http://dx.doi.org/10.1097/YIC.0000000000000027
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author Wang, Po-Sheng
Wu, Shang-Liang
Ching, Han-Yi
author_facet Wang, Po-Sheng
Wu, Shang-Liang
Ching, Han-Yi
author_sort Wang, Po-Sheng
collection PubMed
description The aim of the present study was to investigate the relationship between 10 psychotropic agents and worsening BMI from overweight to obesity among inpatients with schizophrenia. A total of 138 patients with schizophrenia were recruited in this retrospective study. We included 23 patients with worsening BMI, from overweight (24≤BMI<27 kg/m(2)) to obesity (BMI≥27 kg/m(2)), as the case group and 115 patients without a worse BMI as the control group. Data were analyzed to assess the relationships between psychiatric drug use and BMI that worsened from overweight to obesity. Of the 138 patients, 60.9% were men. Their mean age was 47.2±9.7 years, mean age of onset of disease was 32.2±10.4 years, and the mean length of illness 15.0±6.5 years. Valproic acid was found to have a significant impact on the worsening of BMI from overweight to obesity (P<0.05). Age at onset of disease, length of illness, and duration of hospitalization were not associated significantly with worsening of BMI from overweight to obesity. These results call for caution in using valproic acid in schizophrenic inpatients with BMIs indicating overweight or obesity.
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spelling pubmed-40473182014-06-06 The use of psychiatric drugs and worsening body mass index among inpatients with schizophrenia Wang, Po-Sheng Wu, Shang-Liang Ching, Han-Yi Int Clin Psychopharmacol Original Articles The aim of the present study was to investigate the relationship between 10 psychotropic agents and worsening BMI from overweight to obesity among inpatients with schizophrenia. A total of 138 patients with schizophrenia were recruited in this retrospective study. We included 23 patients with worsening BMI, from overweight (24≤BMI<27 kg/m(2)) to obesity (BMI≥27 kg/m(2)), as the case group and 115 patients without a worse BMI as the control group. Data were analyzed to assess the relationships between psychiatric drug use and BMI that worsened from overweight to obesity. Of the 138 patients, 60.9% were men. Their mean age was 47.2±9.7 years, mean age of onset of disease was 32.2±10.4 years, and the mean length of illness 15.0±6.5 years. Valproic acid was found to have a significant impact on the worsening of BMI from overweight to obesity (P<0.05). Age at onset of disease, length of illness, and duration of hospitalization were not associated significantly with worsening of BMI from overweight to obesity. These results call for caution in using valproic acid in schizophrenic inpatients with BMIs indicating overweight or obesity. Lippincott Williams And Wilkins 2014-07 2014-06-26 /pmc/articles/PMC4047318/ /pubmed/24398897 http://dx.doi.org/10.1097/YIC.0000000000000027 Text en © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins http://creativecommons.org/licenses/by-nc-nd/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Original Articles
Wang, Po-Sheng
Wu, Shang-Liang
Ching, Han-Yi
The use of psychiatric drugs and worsening body mass index among inpatients with schizophrenia
title The use of psychiatric drugs and worsening body mass index among inpatients with schizophrenia
title_full The use of psychiatric drugs and worsening body mass index among inpatients with schizophrenia
title_fullStr The use of psychiatric drugs and worsening body mass index among inpatients with schizophrenia
title_full_unstemmed The use of psychiatric drugs and worsening body mass index among inpatients with schizophrenia
title_short The use of psychiatric drugs and worsening body mass index among inpatients with schizophrenia
title_sort use of psychiatric drugs and worsening body mass index among inpatients with schizophrenia
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047318/
https://www.ncbi.nlm.nih.gov/pubmed/24398897
http://dx.doi.org/10.1097/YIC.0000000000000027
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