Cargando…

CD8(+) T-Cell Responses in Acute Hepatitis C Virus Infection

Hepatitis C virus (HCV) infects approximately 170 million people worldwide and is a major cause of life-threatening liver diseases such as liver cirrhosis and hepatocellular carcinoma. Acute HCV infection often progresses to chronic persistent infection, although some patients recover spontaneously....

Descripción completa

Detalles Bibliográficos
Autores principales: Sung, Pil Soo, Racanelli, Vito, Shin, Eui-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047488/
https://www.ncbi.nlm.nih.gov/pubmed/24936203
http://dx.doi.org/10.3389/fimmu.2014.00266
_version_ 1782480404894187520
author Sung, Pil Soo
Racanelli, Vito
Shin, Eui-Cheol
author_facet Sung, Pil Soo
Racanelli, Vito
Shin, Eui-Cheol
author_sort Sung, Pil Soo
collection PubMed
description Hepatitis C virus (HCV) infects approximately 170 million people worldwide and is a major cause of life-threatening liver diseases such as liver cirrhosis and hepatocellular carcinoma. Acute HCV infection often progresses to chronic persistent infection, although some patients recover spontaneously. The divergent outcomes of acute HCV infection are known to be determined by differences in virus-specific T-cell responses among patients. Of the two major T-cell subsets, CD8(+) T-cells are known to be the key effector cells that control viral infections via cytolytic activity and cytokine secretion. Herein, we review various aspects of HCV-specific CD8(+) T-cell responses in acute HCV infection. In particular, we focus on timing of CD8(+) T-cell responses, relationship between CD8(+) T-cell responses and outcomes of acute HCV infection, receptor expression on CD8(+) T-cells, breadth of CD8(+) T-cell responses, and viral mutations.
format Online
Article
Text
id pubmed-4047488
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-40474882014-06-16 CD8(+) T-Cell Responses in Acute Hepatitis C Virus Infection Sung, Pil Soo Racanelli, Vito Shin, Eui-Cheol Front Immunol Immunology Hepatitis C virus (HCV) infects approximately 170 million people worldwide and is a major cause of life-threatening liver diseases such as liver cirrhosis and hepatocellular carcinoma. Acute HCV infection often progresses to chronic persistent infection, although some patients recover spontaneously. The divergent outcomes of acute HCV infection are known to be determined by differences in virus-specific T-cell responses among patients. Of the two major T-cell subsets, CD8(+) T-cells are known to be the key effector cells that control viral infections via cytolytic activity and cytokine secretion. Herein, we review various aspects of HCV-specific CD8(+) T-cell responses in acute HCV infection. In particular, we focus on timing of CD8(+) T-cell responses, relationship between CD8(+) T-cell responses and outcomes of acute HCV infection, receptor expression on CD8(+) T-cells, breadth of CD8(+) T-cell responses, and viral mutations. Frontiers Media S.A. 2014-06-06 /pmc/articles/PMC4047488/ /pubmed/24936203 http://dx.doi.org/10.3389/fimmu.2014.00266 Text en Copyright © 2014 Sung, Racanelli and Shin. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Sung, Pil Soo
Racanelli, Vito
Shin, Eui-Cheol
CD8(+) T-Cell Responses in Acute Hepatitis C Virus Infection
title CD8(+) T-Cell Responses in Acute Hepatitis C Virus Infection
title_full CD8(+) T-Cell Responses in Acute Hepatitis C Virus Infection
title_fullStr CD8(+) T-Cell Responses in Acute Hepatitis C Virus Infection
title_full_unstemmed CD8(+) T-Cell Responses in Acute Hepatitis C Virus Infection
title_short CD8(+) T-Cell Responses in Acute Hepatitis C Virus Infection
title_sort cd8(+) t-cell responses in acute hepatitis c virus infection
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047488/
https://www.ncbi.nlm.nih.gov/pubmed/24936203
http://dx.doi.org/10.3389/fimmu.2014.00266
work_keys_str_mv AT sungpilsoo cd8tcellresponsesinacutehepatitiscvirusinfection
AT racanellivito cd8tcellresponsesinacutehepatitiscvirusinfection
AT shineuicheol cd8tcellresponsesinacutehepatitiscvirusinfection