‘Click cyclic ADP-ribose’: a neutral second messenger mimic

Analogues of the potent Ca(2+) releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca(2+) release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inh...

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Autores principales: Swarbrick, Joanna M., Graeff, Richard, Garnham, Clive, Thomas, Mark P., Galione, Antony, Potter, Barry V. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2014
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047616/
https://www.ncbi.nlm.nih.gov/pubmed/24452494
http://dx.doi.org/10.1039/c3cc49249d
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author Swarbrick, Joanna M.
Graeff, Richard
Garnham, Clive
Thomas, Mark P.
Galione, Antony
Potter, Barry V. L.
author_facet Swarbrick, Joanna M.
Graeff, Richard
Garnham, Clive
Thomas, Mark P.
Galione, Antony
Potter, Barry V. L.
author_sort Swarbrick, Joanna M.
collection PubMed
description Analogues of the potent Ca(2+) releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca(2+) release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators.
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spelling pubmed-40476162014-06-06 ‘Click cyclic ADP-ribose’: a neutral second messenger mimic Swarbrick, Joanna M. Graeff, Richard Garnham, Clive Thomas, Mark P. Galione, Antony Potter, Barry V. L. Chem Commun (Camb) Chemistry Analogues of the potent Ca(2+) releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca(2+) release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators. Royal Society of Chemistry 2014-03-07 2014-01-23 /pmc/articles/PMC4047616/ /pubmed/24452494 http://dx.doi.org/10.1039/c3cc49249d Text en This journal is © The Royal Society of Chemistry 2014 https://creativecommons.org/licenses/by-nc/2.0/uk/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/ (https://creativecommons.org/licenses/by-nc/2.0/uk/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Swarbrick, Joanna M.
Graeff, Richard
Garnham, Clive
Thomas, Mark P.
Galione, Antony
Potter, Barry V. L.
‘Click cyclic ADP-ribose’: a neutral second messenger mimic
title ‘Click cyclic ADP-ribose’: a neutral second messenger mimic
title_full ‘Click cyclic ADP-ribose’: a neutral second messenger mimic
title_fullStr ‘Click cyclic ADP-ribose’: a neutral second messenger mimic
title_full_unstemmed ‘Click cyclic ADP-ribose’: a neutral second messenger mimic
title_short ‘Click cyclic ADP-ribose’: a neutral second messenger mimic
title_sort ‘click cyclic adp-ribose’: a neutral second messenger mimic
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047616/
https://www.ncbi.nlm.nih.gov/pubmed/24452494
http://dx.doi.org/10.1039/c3cc49249d
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