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Fatal adverse drug reactions: Experience of adverse drug reactions in a tertiary care teaching hospital of North India - A case series
Medical burden of fatal adverse drug reactions (FADRs) is significant. The epidemiological data on FADR do exist from the western world, but there is scanty from India. We hereby report a case series of FADRs recorded in a 2 years period. Point prevalence of FADRs was 0.223%. Point prevalence of all...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047694/ https://www.ncbi.nlm.nih.gov/pubmed/24914261 http://dx.doi.org/10.4103/0972-5229.132499 |
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author | Tandon, Vishal R. Khajuria, Vijay Mahajan, Annil Gillani, Zahid Mahajan, Vivek Chandail, Vijant |
author_facet | Tandon, Vishal R. Khajuria, Vijay Mahajan, Annil Gillani, Zahid Mahajan, Vivek Chandail, Vijant |
author_sort | Tandon, Vishal R. |
collection | PubMed |
description | Medical burden of fatal adverse drug reactions (FADRs) is significant. The epidemiological data on FADR do exist from the western world, but there is scanty from India. We hereby report a case series of FADRs recorded in a 2 years period. Point prevalence of FADRs was 0.223%. Point prevalence of all cause death in the hospital was 1.20%. The drugs causing FADRs were injection bupivacaine, amphotericin B, directly observed treatment short-course Category-1, injection streptokinase, and tablet ferrous sulfate. All these FADR were labeled as possible expect one case as probable. All FADR were labeled as type A. In three out of five the central nervous system was involved, while the hepatic system and multiorgan failure accounted for one case each. Two cases each were acute and subacute, while one was latent in nature. Reporting of FADRs shall go a long way in patient safety. |
format | Online Article Text |
id | pubmed-4047694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-40476942014-06-09 Fatal adverse drug reactions: Experience of adverse drug reactions in a tertiary care teaching hospital of North India - A case series Tandon, Vishal R. Khajuria, Vijay Mahajan, Annil Gillani, Zahid Mahajan, Vivek Chandail, Vijant Indian J Crit Care Med Short Communication Medical burden of fatal adverse drug reactions (FADRs) is significant. The epidemiological data on FADR do exist from the western world, but there is scanty from India. We hereby report a case series of FADRs recorded in a 2 years period. Point prevalence of FADRs was 0.223%. Point prevalence of all cause death in the hospital was 1.20%. The drugs causing FADRs were injection bupivacaine, amphotericin B, directly observed treatment short-course Category-1, injection streptokinase, and tablet ferrous sulfate. All these FADR were labeled as possible expect one case as probable. All FADR were labeled as type A. In three out of five the central nervous system was involved, while the hepatic system and multiorgan failure accounted for one case each. Two cases each were acute and subacute, while one was latent in nature. Reporting of FADRs shall go a long way in patient safety. Medknow Publications & Media Pvt Ltd 2014-05 /pmc/articles/PMC4047694/ /pubmed/24914261 http://dx.doi.org/10.4103/0972-5229.132499 Text en Copyright: © Indian Journal of Critical Care Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Tandon, Vishal R. Khajuria, Vijay Mahajan, Annil Gillani, Zahid Mahajan, Vivek Chandail, Vijant Fatal adverse drug reactions: Experience of adverse drug reactions in a tertiary care teaching hospital of North India - A case series |
title | Fatal adverse drug reactions: Experience of adverse drug reactions in a tertiary care teaching hospital of North India - A case series |
title_full | Fatal adverse drug reactions: Experience of adverse drug reactions in a tertiary care teaching hospital of North India - A case series |
title_fullStr | Fatal adverse drug reactions: Experience of adverse drug reactions in a tertiary care teaching hospital of North India - A case series |
title_full_unstemmed | Fatal adverse drug reactions: Experience of adverse drug reactions in a tertiary care teaching hospital of North India - A case series |
title_short | Fatal adverse drug reactions: Experience of adverse drug reactions in a tertiary care teaching hospital of North India - A case series |
title_sort | fatal adverse drug reactions: experience of adverse drug reactions in a tertiary care teaching hospital of north india - a case series |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047694/ https://www.ncbi.nlm.nih.gov/pubmed/24914261 http://dx.doi.org/10.4103/0972-5229.132499 |
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