Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells

Lymphangioleiomyomatosis (LAM) is a female-predominant interstitial lung disease that can lead to respiratory failure. LAM cells typically have inactivating TSC2 mutations, leading to mTORC1 activation. The gender specificity of LAM suggests that estradiol contributes to disease development, yet the...

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Detalles Bibliográficos
Autores principales: Sun, Y, Gu, X, Zhang, E, Park, M-A, Pereira, A M, Wang, S, Morrison, T, Li, C, Blenis, J, Gerbaudo, V H, Henske, E P, Yu, J J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047866/
https://www.ncbi.nlm.nih.gov/pubmed/24832603
http://dx.doi.org/10.1038/cddis.2014.204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047866/
https://www.ncbi.nlm.nih.gov/pubmed/24832603
http://dx.doi.org/10.1038/cddis.2014.204

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