Cargando…

Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells

Lymphangioleiomyomatosis (LAM) is a female-predominant interstitial lung disease that can lead to respiratory failure. LAM cells typically have inactivating TSC2 mutations, leading to mTORC1 activation. The gender specificity of LAM suggests that estradiol contributes to disease development, yet the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Y, Gu, X, Zhang, E, Park, M-A, Pereira, A M, Wang, S, Morrison, T, Li, C, Blenis, J, Gerbaudo, V H, Henske, E P, Yu, J J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047866/ https://www.ncbi.nlm.nih.gov/pubmed/24832603 http://dx.doi.org/10.1038/cddis.2014.204

Ejemplares similares

Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells
por: Li, Chenggang, et al.
Publicado: (2014)

Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1
por: Buel, Gwen R., et al.
Publicado: (2022)

Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1
por: Du, Heng, et al.
Publicado: (2023)

Hyperactivity of mTORC1 or mTORC2-dependent signaling causes epilepsy downstream of somatic PTEN loss
por: Cullen, Erin R., et al.
Publicado: (2023)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

Dihydroxyacetone phosphate signals glucose availability to mTORC1
por: Orozco, Jose M., et al.
Publicado: (2020)

GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells
por: Joha, S, et al.
Publicado: (2012)

Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation.
por: Balcazar Morales, Norman, et al.
Publicado: (2012)

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2
por: Humphrey, Sean J., et al.
Publicado: (2013)

Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells
por: Dunlop, Elaine A., et al.
Publicado: (2017)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Pentose Phosphate Pathway Reactions in Photosynthesizing Cells
por: Sharkey, Thomas D.
Publicado: (2021)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

mTORC1 hyperactivation in lymphangioleiomyomatosis leads to ACE2 upregulation in type II pneumocytes: implications for COVID-19
por: Tang, Yan, et al.
Publicado: (2021)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt
por: Meng, Haitao, et al.
Publicado: (2013)

17ß-Estradiol Regulates mTORC2 Sensitivity to Rapamycin in Adaptive Cardiac Remodeling
por: Kusch, Angelika, et al.
Publicado: (2015)

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
por: Porstmann, Thomas, et al.
Publicado: (2008)

Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability
por: Mutvei, Anders P., et al.
Publicado: (2020)

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis
por: Liu, Pengda, et al.
Publicado: (2013)

DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium
por: Cai, Jiyang, et al.
Publicado: (2022)

High glutamine suppresses osteogenesis through mTORC1-mediated inhibition of the mTORC2/AKT-473/RUNX2 axis
por: Gayatri, Meher Bolisetti, et al.
Publicado: (2022)

Cellular recycling gone wrong: The role of dysregulated autophagy and hyperactive mTORC1 in the pathogenesis of sarcoidosis
por: Adouli, Jennifer N., et al.
Publicado: (2023)

Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells
por: Shin, Seung Ho, et al.
Publicado: (2020)

Inhibition of mTORC2/Akt signaling to enhance the therapeutic potential of CD8 T cells
por: Zhang, Lianjun, et al.
Publicado: (2015)

The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back
por: Rehbein, Ulrike, et al.
Publicado: (2021)

mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion
por: Liu, Heng-Jia, et al.
Publicado: (2023)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
por: Miao, Linqing, et al.
Publicado: (2016)

RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes
por: Weinberg, Mark A.
Publicado: (2016)

Fundamental Role of Pentose Phosphate Pathway within the Endoplasmic Reticulum in Glutamine Addiction of Triple-Negative Breast Cancer Cells
por: Marini, Cecilia, et al.
Publicado: (2022)

Regulation of the pentose phosphate pathway in cancer
por: Jiang, Peng, et al.
Publicado: (2014)

Queueing theory model of pentose phosphate pathway
por: Kloska, Sylwester M., et al.
Publicado: (2022)

The Entner-Doudoroff and Nonoxidative Pentose Phosphate Pathways Bypass Glycolysis and the Oxidative Pentose Phosphate Pathway in Ralstonia solanacearum
por: Jyoti, Poonam, et al.
Publicado: (2020)

mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs to Coordinate Osteoblastic Differentiation in Mesenchymal Stromal Cells
por: Schaub, Theres, et al.
Publicado: (2019)

Folliculin regulates cell–cell adhesion, AMPK, and mTORC1 in a cell‐type‐specific manner in lung‐derived cells
por: Khabibullin, Damir, et al.
Publicado: (2014)

Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus
por: Zhou, Xin, et al.
Publicado: (2020)

TAp73 enhances the pentose phosphate pathway and supports cell proliferation
por: Du, Wenjing, et al.
Publicado: (2013)

Two high-rate pentose-phosphate pathways in cancer cells
por: Cossu, Vanessa, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ird8aa03dekothsbkq2ob3ehp8