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Senescence induced by RECQL4 dysfunction contributes to Rothmund–Thomson syndrome features in mice

Cellular senescence refers to irreversible growth arrest of primary eukaryotic cells, a process thought to contribute to aging-related degeneration and disease. Deficiency of RecQ helicase RECQL4 leads to Rothmund–Thomson syndrome (RTS), and we have investigated whether senescence is involved using...

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Detalles Bibliográficos
Autores principales:	Lu, H, Fang, E F, Sykora, P, Kulikowicz, T, Zhang, Y, Becker, K G, Croteau, D L, Bohr, V A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047874/ https://www.ncbi.nlm.nih.gov/pubmed/24832598 http://dx.doi.org/10.1038/cddis.2014.168

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