Bioactive lipids and the control of Bax pro-apoptotic activity

Lipids are key regulators of cell physiology through the control of many aspects of cellular life and survival. In particular, lipids have been implicated at different levels and through many different mechanisms in the cell death program called apoptosis. Here, we discuss the action of lipids in th...

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Detalles Bibliográficos
Autores principales: Mignard, V, Lalier, L, Paris, F, Vallette, F M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047880/
https://www.ncbi.nlm.nih.gov/pubmed/24874738
http://dx.doi.org/10.1038/cddis.2014.226
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author Mignard, V
Lalier, L
Paris, F
Vallette, F M
author_facet Mignard, V
Lalier, L
Paris, F
Vallette, F M
author_sort Mignard, V
collection PubMed
description Lipids are key regulators of cell physiology through the control of many aspects of cellular life and survival. In particular, lipids have been implicated at different levels and through many different mechanisms in the cell death program called apoptosis. Here, we discuss the action of lipids in the regulation of the activation and the integration of Bax into the mitochondrial outer membrane, a key pro-apoptotic member of the BCL-2 family. We describe how, during apoptosis, lipids can act simultaneously or in parallel as receptors or ligands for Bax to stimulate or inhibit its pro-death activity.
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spelling pubmed-40478802014-06-12 Bioactive lipids and the control of Bax pro-apoptotic activity Mignard, V Lalier, L Paris, F Vallette, F M Cell Death Dis Review Lipids are key regulators of cell physiology through the control of many aspects of cellular life and survival. In particular, lipids have been implicated at different levels and through many different mechanisms in the cell death program called apoptosis. Here, we discuss the action of lipids in the regulation of the activation and the integration of Bax into the mitochondrial outer membrane, a key pro-apoptotic member of the BCL-2 family. We describe how, during apoptosis, lipids can act simultaneously or in parallel as receptors or ligands for Bax to stimulate or inhibit its pro-death activity. Nature Publishing Group 2014-05 2014-05-29 /pmc/articles/PMC4047880/ /pubmed/24874738 http://dx.doi.org/10.1038/cddis.2014.226 Text en Copyright © 2014 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Review
Mignard, V
Lalier, L
Paris, F
Vallette, F M
Bioactive lipids and the control of Bax pro-apoptotic activity
title Bioactive lipids and the control of Bax pro-apoptotic activity
title_full Bioactive lipids and the control of Bax pro-apoptotic activity
title_fullStr Bioactive lipids and the control of Bax pro-apoptotic activity
title_full_unstemmed Bioactive lipids and the control of Bax pro-apoptotic activity
title_short Bioactive lipids and the control of Bax pro-apoptotic activity
title_sort bioactive lipids and the control of bax pro-apoptotic activity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047880/
https://www.ncbi.nlm.nih.gov/pubmed/24874738
http://dx.doi.org/10.1038/cddis.2014.226
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