DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B

The disruption of DNA replication in cells triggers checkpoint responses that slow-down S-phase progression and protect replication fork integrity. These checkpoints are also determinants of cell fate and can help maintain cell viability or trigger cell death pathways. CHK1 has a pivotal role in suc...

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Detalles Bibliográficos
Autores principales: Zuazua-Villar, P, Rodriguez, R, Gagou, M E, Eyers, P A, Meuth, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047883/
https://www.ncbi.nlm.nih.gov/pubmed/24853431
http://dx.doi.org/10.1038/cddis.2014.231

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