The pleiotropic roles of sphingolipid signaling in autophagy

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The autophagic process involves encompassing damaged proteins and organelles within double- or multi-membraned structures and delivering these molecules to the lytic compartments of vacuoles. Sphingolipids (SLs), which are ubiquitous membrane lipids in eukaryotes, participate in the generation of va...

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Autores principales: Li, Y, Li, S, Qin, X, Hou, W, Dong, H, Yao, L, Xiong, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047895/
https://www.ncbi.nlm.nih.gov/pubmed/24853423
http://dx.doi.org/10.1038/cddis.2014.215
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author Li, Y
Li, S
Qin, X
Hou, W
Dong, H
Yao, L
Xiong, L
author_facet Li, Y
Li, S
Qin, X
Hou, W
Dong, H
Yao, L
Xiong, L
author_sort Li, Y
collection PubMed
description The autophagic process involves encompassing damaged proteins and organelles within double- or multi-membraned structures and delivering these molecules to the lytic compartments of vacuoles. Sphingolipids (SLs), which are ubiquitous membrane lipids in eukaryotes, participate in the generation of various membrane structures, including rafts, caveolae, and cytosolic vesicles. SLs are a complex family of molecules that have a growing number of members, including ceramide, sphingosine-1-phosphate, and dihydroceramide, which have been associated with the essential cellular process of autophagy. This review highlights recent studies focusing on the regulation and function of SL-associated autophagy and its role in cell fate, diseases, and therapeutic interventions.
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spelling pubmed-40478952014-06-12 The pleiotropic roles of sphingolipid signaling in autophagy Li, Y Li, S Qin, X Hou, W Dong, H Yao, L Xiong, L Cell Death Dis Review The autophagic process involves encompassing damaged proteins and organelles within double- or multi-membraned structures and delivering these molecules to the lytic compartments of vacuoles. Sphingolipids (SLs), which are ubiquitous membrane lipids in eukaryotes, participate in the generation of various membrane structures, including rafts, caveolae, and cytosolic vesicles. SLs are a complex family of molecules that have a growing number of members, including ceramide, sphingosine-1-phosphate, and dihydroceramide, which have been associated with the essential cellular process of autophagy. This review highlights recent studies focusing on the regulation and function of SL-associated autophagy and its role in cell fate, diseases, and therapeutic interventions. Nature Publishing Group 2014-05 2014-05-22 /pmc/articles/PMC4047895/ /pubmed/24853423 http://dx.doi.org/10.1038/cddis.2014.215 Text en Copyright © 2014 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-sa/3.0/ Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Review
Li, Y
Li, S
Qin, X
Hou, W
Dong, H
Yao, L
Xiong, L
The pleiotropic roles of sphingolipid signaling in autophagy
title The pleiotropic roles of sphingolipid signaling in autophagy
title_full The pleiotropic roles of sphingolipid signaling in autophagy
title_fullStr The pleiotropic roles of sphingolipid signaling in autophagy
title_full_unstemmed The pleiotropic roles of sphingolipid signaling in autophagy
title_short The pleiotropic roles of sphingolipid signaling in autophagy
title_sort pleiotropic roles of sphingolipid signaling in autophagy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047895/
https://www.ncbi.nlm.nih.gov/pubmed/24853423
http://dx.doi.org/10.1038/cddis.2014.215
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