Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo

Glioblastoma (GBM) is the most common and deadly adult brain tumor. Despite aggressive surgery, radiation, and chemotherapy, the life expectancy of patients diagnosed with GBM is ∼14 months. The extremely aggressive nature of GBM results from glioblastoma stem-like cells (GSCs) that sustain GBM grow...

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Detalles Bibliográficos
Autores principales: Signore, M, Pelacchi, F, di Martino, S, Runci, D, Biffoni, M, Giannetti, S, Morgante, L, De Majo, M, Petricoin, E F, Stancato, L, Larocca, L M, De Maria, R, Pallini, R, Ricci-Vitiani, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047898/
https://www.ncbi.nlm.nih.gov/pubmed/24810059
http://dx.doi.org/10.1038/cddis.2014.188

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