IRE1a constitutes a negative feedback loop with BMP2 and acts as a novel mediator in modulating osteogenic differentiation

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Bone morphogenetic protein 2 (BMP2) is known to activate unfolded protein response (UPR) signaling molecules, such as BiP (IgH chain-binding protein), PERK (PKR-like ER-resistant kinase), and IRE1α. Inositol-requiring enzyme-1a (IRE1a), as one of three unfolded protein sensors in UPR signaling pathw...

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Detalles Bibliográficos
Autores principales: Guo, F-J, Jiang, R, Xiong, Z, Xia, F, Li, M, Chen, L, Liu, C-J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047903/
https://www.ncbi.nlm.nih.gov/pubmed/24853417
http://dx.doi.org/10.1038/cddis.2014.194

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