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Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment
The synthesis of a novel functional biomaterial for wound healing treatment was carried out by adopting a free-radical grafting procedure in aqueous media. With this aim, ciprofloxacin (CFX) was covalently incorporated into collagen (T1C) chains employing an ascorbic acid/hydrogen peroxide redox pai...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047932/ https://www.ncbi.nlm.nih.gov/pubmed/24955537 http://dx.doi.org/10.3390/jfb3020361 |
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| author | Puoci, Francesco Piangiolino, Cristiana Givigliano, Francesco Parisi, Ortensia Ilaria Cassano, Roberta Trombino, Sonia Curcio, Manuela Iemma, Francesca Cirillo, Giuseppe Spizzirri, Umile Gianfranco Restuccia, Donatella Muzzalupo, Rita Picci, Nevio |
| author_facet | Puoci, Francesco Piangiolino, Cristiana Givigliano, Francesco Parisi, Ortensia Ilaria Cassano, Roberta Trombino, Sonia Curcio, Manuela Iemma, Francesca Cirillo, Giuseppe Spizzirri, Umile Gianfranco Restuccia, Donatella Muzzalupo, Rita Picci, Nevio |
| author_sort | Puoci, Francesco |
| collection | PubMed |
| description | The synthesis of a novel functional biomaterial for wound healing treatment was carried out by adopting a free-radical grafting procedure in aqueous media. With this aim, ciprofloxacin (CFX) was covalently incorporated into collagen (T1C) chains employing an ascorbic acid/hydrogen peroxide redox pair as biocompatible initiator system. The covalent insertion of CFX in the polymeric chains was confirmed by FT-IR and UV analyses, while an antibacterial assay demonstrated the activity of the synthesized conjugate against Staphylococcus aureus and Escherichia coli, microorganisms that commonly infect wounds. A catechin blended conjugate was also tested in order to evaluate the ability to influence fibroblast cell growth. The observed antibacterial activity and stimulation of fibroblast growth support the applicability of CFX-T1C conjugate in wound treatment encouraging the healing process. |
| format | Online Article Text |
| id | pubmed-4047932 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-40479322014-06-12 Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment Puoci, Francesco Piangiolino, Cristiana Givigliano, Francesco Parisi, Ortensia Ilaria Cassano, Roberta Trombino, Sonia Curcio, Manuela Iemma, Francesca Cirillo, Giuseppe Spizzirri, Umile Gianfranco Restuccia, Donatella Muzzalupo, Rita Picci, Nevio J Funct Biomater Article The synthesis of a novel functional biomaterial for wound healing treatment was carried out by adopting a free-radical grafting procedure in aqueous media. With this aim, ciprofloxacin (CFX) was covalently incorporated into collagen (T1C) chains employing an ascorbic acid/hydrogen peroxide redox pair as biocompatible initiator system. The covalent insertion of CFX in the polymeric chains was confirmed by FT-IR and UV analyses, while an antibacterial assay demonstrated the activity of the synthesized conjugate against Staphylococcus aureus and Escherichia coli, microorganisms that commonly infect wounds. A catechin blended conjugate was also tested in order to evaluate the ability to influence fibroblast cell growth. The observed antibacterial activity and stimulation of fibroblast growth support the applicability of CFX-T1C conjugate in wound treatment encouraging the healing process. MDPI 2012-05-15 /pmc/articles/PMC4047932/ /pubmed/24955537 http://dx.doi.org/10.3390/jfb3020361 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| spellingShingle | Article Puoci, Francesco Piangiolino, Cristiana Givigliano, Francesco Parisi, Ortensia Ilaria Cassano, Roberta Trombino, Sonia Curcio, Manuela Iemma, Francesca Cirillo, Giuseppe Spizzirri, Umile Gianfranco Restuccia, Donatella Muzzalupo, Rita Picci, Nevio Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment |
| title | Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment |
| title_full | Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment |
| title_fullStr | Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment |
| title_full_unstemmed | Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment |
| title_short | Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment |
| title_sort | ciprofloxacin-collagen conjugate in the wound healing treatment |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047932/ https://www.ncbi.nlm.nih.gov/pubmed/24955537 http://dx.doi.org/10.3390/jfb3020361 |
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