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Design of activated serine-containing catalytic triads with atomic level accuracy
A challenge in the computational design of enzymes is that multiple properties must be simultaneously optimized -- substrate-binding, transition state stabilization, and product release -- and this has limited the absolute activity of successful designs. Here, we focus on a single critical property...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048123/ https://www.ncbi.nlm.nih.gov/pubmed/24705591 http://dx.doi.org/10.1038/nchembio.1498 |