Nonstructural Protein 5A Is Incorporated into Hepatitis C Virus Low-Density Particle through Interaction with Core Protein and Microtubules during Intracellular Transport

Nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) serves dual functions in viral RNA replication and virus assembly. Here, we demonstrate that HCV replication complex along with NS5A and Core protein was transported to the lipid droplet (LD) through microtubules, and NS5A-Core complexes wer...

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Detalles Bibliográficos
Autores principales: Lai, Chao-Kuen, Saxena, Vikas, Tseng, Chung-Hsin, Jeng, King-Song, Kohara, Michinori, Lai, Michael M. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048239/
https://www.ncbi.nlm.nih.gov/pubmed/24905011
http://dx.doi.org/10.1371/journal.pone.0099022

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