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CLOCK 3111 T/C SNP Interacts with Emotional Eating Behavior for Weight-Loss in a Mediterranean Population

OBJECTIVE: The goals of this research was (1) to analyze the role of emotional eating behavior on weight-loss progression during a 30-week weight-loss program in 1,272 individuals from a large Mediterranean population and (2) to test for interaction between CLOCK 3111 T/C SNP and emotional eating be...

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Autores principales: López-Guimerà, Gemma, Dashti, Hassan S., Smith, Caren E., Sánchez-Carracedo, David, Ordovas, Jose M., Garaulet, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048277/
https://www.ncbi.nlm.nih.gov/pubmed/24905098
http://dx.doi.org/10.1371/journal.pone.0099152
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author López-Guimerà, Gemma
Dashti, Hassan S.
Smith, Caren E.
Sánchez-Carracedo, David
Ordovas, Jose M.
Garaulet, Marta
author_facet López-Guimerà, Gemma
Dashti, Hassan S.
Smith, Caren E.
Sánchez-Carracedo, David
Ordovas, Jose M.
Garaulet, Marta
author_sort López-Guimerà, Gemma
collection PubMed
description OBJECTIVE: The goals of this research was (1) to analyze the role of emotional eating behavior on weight-loss progression during a 30-week weight-loss program in 1,272 individuals from a large Mediterranean population and (2) to test for interaction between CLOCK 3111 T/C SNP and emotional eating behavior on the effectiveness of the weight-loss program. DESIGN AND METHODS: A total of 1,272 overweight and obese participants (BMI: 31±5 kg/m(2)), aged 20 to 65 years, attending outpatient weight-loss clinics were recruited for this analysis. Emotional eating behavior was assessed by the Emotional Eating Questionnaire (EEQ), a questionnaire validated for overweight and obese Spanish subjects. Anthropometric measures, dietary intake and weight-loss progression were assessed and analyzed throughout the 30-week program. Multivariate analysis and linear regression models were performed to test for gene-environment interaction. RESULTS: Weight-loss progression during the 30-week program differed significantly according to the degree of emotional eating behavior. Participants classified as ‘very emotional eaters’ experienced more irregular (P = 0.007) weight-loss, with a lower rate of weight decline (−0.002 vs. −0.003, P<0.05) in comparison with less emotional eaters. The percentage of weight-loss was also significantly higher in ‘non-emotional eaters’ (P = 0.009). Additionally, we identified a significant gene-environment interaction associated with weight-loss at the CLOCK 3111 T/C locus (P = 0.017). By dichotomizing the emotional eating behavior score, linear regression analysis indicated that minor C allele carriers with a high emotional score (> = 11), lost significantly less weight than those C carriers with a low emotional score (<11) (P = 0.005). CONCLUSIONS: Emotional eating behavior associates with weight-loss pattern, progression and total weight-loss. Additionally, CLOCK 3111 T/C SNP interacts with emotional eating behavior to modulate total weight loss. These results suggest that the assessment of this locus and emotional eating behavior could improve the development of effective, long-tern weight-management interventions.
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spelling pubmed-40482772014-06-09 CLOCK 3111 T/C SNP Interacts with Emotional Eating Behavior for Weight-Loss in a Mediterranean Population López-Guimerà, Gemma Dashti, Hassan S. Smith, Caren E. Sánchez-Carracedo, David Ordovas, Jose M. Garaulet, Marta PLoS One Research Article OBJECTIVE: The goals of this research was (1) to analyze the role of emotional eating behavior on weight-loss progression during a 30-week weight-loss program in 1,272 individuals from a large Mediterranean population and (2) to test for interaction between CLOCK 3111 T/C SNP and emotional eating behavior on the effectiveness of the weight-loss program. DESIGN AND METHODS: A total of 1,272 overweight and obese participants (BMI: 31±5 kg/m(2)), aged 20 to 65 years, attending outpatient weight-loss clinics were recruited for this analysis. Emotional eating behavior was assessed by the Emotional Eating Questionnaire (EEQ), a questionnaire validated for overweight and obese Spanish subjects. Anthropometric measures, dietary intake and weight-loss progression were assessed and analyzed throughout the 30-week program. Multivariate analysis and linear regression models were performed to test for gene-environment interaction. RESULTS: Weight-loss progression during the 30-week program differed significantly according to the degree of emotional eating behavior. Participants classified as ‘very emotional eaters’ experienced more irregular (P = 0.007) weight-loss, with a lower rate of weight decline (−0.002 vs. −0.003, P<0.05) in comparison with less emotional eaters. The percentage of weight-loss was also significantly higher in ‘non-emotional eaters’ (P = 0.009). Additionally, we identified a significant gene-environment interaction associated with weight-loss at the CLOCK 3111 T/C locus (P = 0.017). By dichotomizing the emotional eating behavior score, linear regression analysis indicated that minor C allele carriers with a high emotional score (> = 11), lost significantly less weight than those C carriers with a low emotional score (<11) (P = 0.005). CONCLUSIONS: Emotional eating behavior associates with weight-loss pattern, progression and total weight-loss. Additionally, CLOCK 3111 T/C SNP interacts with emotional eating behavior to modulate total weight loss. These results suggest that the assessment of this locus and emotional eating behavior could improve the development of effective, long-tern weight-management interventions. Public Library of Science 2014-06-06 /pmc/articles/PMC4048277/ /pubmed/24905098 http://dx.doi.org/10.1371/journal.pone.0099152 Text en © 2014 López-Guimerà et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
López-Guimerà, Gemma
Dashti, Hassan S.
Smith, Caren E.
Sánchez-Carracedo, David
Ordovas, Jose M.
Garaulet, Marta
CLOCK 3111 T/C SNP Interacts with Emotional Eating Behavior for Weight-Loss in a Mediterranean Population
title CLOCK 3111 T/C SNP Interacts with Emotional Eating Behavior for Weight-Loss in a Mediterranean Population
title_full CLOCK 3111 T/C SNP Interacts with Emotional Eating Behavior for Weight-Loss in a Mediterranean Population
title_fullStr CLOCK 3111 T/C SNP Interacts with Emotional Eating Behavior for Weight-Loss in a Mediterranean Population
title_full_unstemmed CLOCK 3111 T/C SNP Interacts with Emotional Eating Behavior for Weight-Loss in a Mediterranean Population
title_short CLOCK 3111 T/C SNP Interacts with Emotional Eating Behavior for Weight-Loss in a Mediterranean Population
title_sort clock 3111 t/c snp interacts with emotional eating behavior for weight-loss in a mediterranean population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048277/
https://www.ncbi.nlm.nih.gov/pubmed/24905098
http://dx.doi.org/10.1371/journal.pone.0099152
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