Uterine smooth muscle tumors with features suggesting fumarate hydratase aberration: detailed morphologic analysis and correlation with S-(2-succino)-cysteine immunohistochemistry

Rare, sporadic uterine leiomyomas arise in the setting of severe metabolic aberration due to somatic fumarate hydratase mutation. Germline mutations account for the Hereditary Leiomyomatosis and Renal Cell Carcinoma syndrome, which predisposes for cutaneous and uterine leiomyomas and aggressive rena...

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Detalles Bibliográficos
Autores principales: Reyes, Carolina, Karamurzin, Yevgeniy, Frizzell, Norma, Garg, Karuna, Nonaka, Daisuke, Chen, Ying-Bei, Soslow, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048336/
https://www.ncbi.nlm.nih.gov/pubmed/24309325
http://dx.doi.org/10.1038/modpathol.2013.215

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