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High-intensity intermittent cycling increases purine loss compared with workload-matched continuous moderate intensity cycling
PURPOSE: Exercise at 50–60 % of peak oxygen consumption (VO(2 peak)) stimulates maximal fat oxidation rates. Despite a lower estimated work performed; high-intensity intermittent exercise (HIIE) training produces greater fat mass reductions when compared with workload-matched continuous (CON) steady...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048667/ https://www.ncbi.nlm.nih.gov/pubmed/24748529 http://dx.doi.org/10.1007/s00421-014-2878-x |
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author | Gerber, Tracey Borg, Melissa Louise Hayes, Alan Stathis, Christos George |
author_facet | Gerber, Tracey Borg, Melissa Louise Hayes, Alan Stathis, Christos George |
author_sort | Gerber, Tracey |
collection | PubMed |
description | PURPOSE: Exercise at 50–60 % of peak oxygen consumption (VO(2 peak)) stimulates maximal fat oxidation rates. Despite a lower estimated work performed; high-intensity intermittent exercise (HIIE) training produces greater fat mass reductions when compared with workload-matched continuous (CON) steady state exercise. No metabolic basis has been documented nor mechanisms offered to explain this anomaly. This study investigated the physiological and metabolic responses of two different workload-matched exercise protocols. METHODS: On separate occasions and at least 1 week apart, eight apparently healthy males cycled for 30 min at either 50 % VO(2 peak) (CON) or performed repeated 20 s bouts of supramaximal exercise at 150 %VO(2 peak) separated by 40 s rest (HIIE). RESULTS: The average heart rate, oxygen consumption, plasma glycerol and free fatty acid concentrations were not different during exercise and recovery between the trials. Plasma lactate and hypoxanthine (Hx) concentrations were elevated and urinary excretion rates of Hx and uric acid were greater following HIIE as compared to CON (P < 0.05). CONCLUSION: Exercise-induced plasma Hx accumulation and urinary purine excretion are greater following HIIE and indirectly represents a net loss of adenosine triphosphate (ATP) from the muscle. The subsequent restorative processes required for intramuscular de novo replacement of ATP may contribute to a negative energy balance and in part, account for the potential accelerated fat loss observed with HIIE when compared with CON training programs. |
format | Online Article Text |
id | pubmed-4048667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-40486672014-06-16 High-intensity intermittent cycling increases purine loss compared with workload-matched continuous moderate intensity cycling Gerber, Tracey Borg, Melissa Louise Hayes, Alan Stathis, Christos George Eur J Appl Physiol Original Article PURPOSE: Exercise at 50–60 % of peak oxygen consumption (VO(2 peak)) stimulates maximal fat oxidation rates. Despite a lower estimated work performed; high-intensity intermittent exercise (HIIE) training produces greater fat mass reductions when compared with workload-matched continuous (CON) steady state exercise. No metabolic basis has been documented nor mechanisms offered to explain this anomaly. This study investigated the physiological and metabolic responses of two different workload-matched exercise protocols. METHODS: On separate occasions and at least 1 week apart, eight apparently healthy males cycled for 30 min at either 50 % VO(2 peak) (CON) or performed repeated 20 s bouts of supramaximal exercise at 150 %VO(2 peak) separated by 40 s rest (HIIE). RESULTS: The average heart rate, oxygen consumption, plasma glycerol and free fatty acid concentrations were not different during exercise and recovery between the trials. Plasma lactate and hypoxanthine (Hx) concentrations were elevated and urinary excretion rates of Hx and uric acid were greater following HIIE as compared to CON (P < 0.05). CONCLUSION: Exercise-induced plasma Hx accumulation and urinary purine excretion are greater following HIIE and indirectly represents a net loss of adenosine triphosphate (ATP) from the muscle. The subsequent restorative processes required for intramuscular de novo replacement of ATP may contribute to a negative energy balance and in part, account for the potential accelerated fat loss observed with HIIE when compared with CON training programs. Springer Berlin Heidelberg 2014-04-19 2014 /pmc/articles/PMC4048667/ /pubmed/24748529 http://dx.doi.org/10.1007/s00421-014-2878-x Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Article Gerber, Tracey Borg, Melissa Louise Hayes, Alan Stathis, Christos George High-intensity intermittent cycling increases purine loss compared with workload-matched continuous moderate intensity cycling |
title | High-intensity intermittent cycling increases purine loss compared with workload-matched continuous moderate intensity cycling |
title_full | High-intensity intermittent cycling increases purine loss compared with workload-matched continuous moderate intensity cycling |
title_fullStr | High-intensity intermittent cycling increases purine loss compared with workload-matched continuous moderate intensity cycling |
title_full_unstemmed | High-intensity intermittent cycling increases purine loss compared with workload-matched continuous moderate intensity cycling |
title_short | High-intensity intermittent cycling increases purine loss compared with workload-matched continuous moderate intensity cycling |
title_sort | high-intensity intermittent cycling increases purine loss compared with workload-matched continuous moderate intensity cycling |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048667/ https://www.ncbi.nlm.nih.gov/pubmed/24748529 http://dx.doi.org/10.1007/s00421-014-2878-x |
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