Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole–imidazole polyamide, which targets an E-box motif

Gene amplification and/or overexpression of the transcription factor c-MYC, which binds to the E-box sequence (5′-CACGTG-3′), has been observed in many human tumors. In this study, we have designed 5 pyrrole–imidazole (PI) polyamides recognizing E-box, and found that, among them, Myc-6 significantly...

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Detalles Bibliográficos
Autores principales: Taniguchi, Masashi, Fujiwara, Kyoko, Nakai, Yuji, Ozaki, Toshinori, Koshikawa, Nobuko, Toshio, Kojima, Kataba, Motoaki, Oguni, Asako, Matsuda, Hiroyuki, Yoshida, Yukihiro, Tokuhashi, Yasuaki, Fukuda, Noboru, Ueno, Takahiro, Soma, Masayoshi, Nagase, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048845/
https://www.ncbi.nlm.nih.gov/pubmed/24918046
http://dx.doi.org/10.1016/j.fob.2014.03.004

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