Discovery and saturation analysis of cancer genes across 21 tumor types

While a few cancer genes are mutated in a high proportion of tumors of a given type (>20%), most are mutated at intermediate frequencies (2–20%). To explore the feasibility of creating a comprehensive catalog of cancer genes, we analyzed somatic point mutations in exome sequence from 4,742 tumor-...

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Detalles Bibliográficos
Autores principales: Lawrence, Michael S., Stojanov, Petar, Mermel, Craig H., Garraway, Levi A., Golub, Todd R., Meyerson, Matthew, Gabriel, Stacey B., Lander, Eric S., Getz, Gad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048962/
https://www.ncbi.nlm.nih.gov/pubmed/24390350
http://dx.doi.org/10.1038/nature12912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048962/
https://www.ncbi.nlm.nih.gov/pubmed/24390350
http://dx.doi.org/10.1038/nature12912

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