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Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst
[Image: see text] A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides wi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049244/ https://www.ncbi.nlm.nih.gov/pubmed/24762125 http://dx.doi.org/10.1021/jo500662s |
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author | Cheung, Chi Wai Buchwald, Stephen L. |
author_facet | Cheung, Chi Wai Buchwald, Stephen L. |
author_sort | Cheung, Chi Wai |
collection | PubMed |
description | [Image: see text] A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield. |
format | Online Article Text |
id | pubmed-4049244 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-40492442015-04-24 Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst Cheung, Chi Wai Buchwald, Stephen L. J Org Chem [Image: see text] A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield. American Chemical Society 2014-04-24 2014-06-06 /pmc/articles/PMC4049244/ /pubmed/24762125 http://dx.doi.org/10.1021/jo500662s Text en Copyright © 2014 American Chemical Society |
spellingShingle | Cheung, Chi Wai Buchwald, Stephen L. Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst |
title | Palladium-Catalyzed Hydroxylation
of Aryl and Heteroaryl
Halides Enabled by the Use of a Palladacycle Precatalyst |
title_full | Palladium-Catalyzed Hydroxylation
of Aryl and Heteroaryl
Halides Enabled by the Use of a Palladacycle Precatalyst |
title_fullStr | Palladium-Catalyzed Hydroxylation
of Aryl and Heteroaryl
Halides Enabled by the Use of a Palladacycle Precatalyst |
title_full_unstemmed | Palladium-Catalyzed Hydroxylation
of Aryl and Heteroaryl
Halides Enabled by the Use of a Palladacycle Precatalyst |
title_short | Palladium-Catalyzed Hydroxylation
of Aryl and Heteroaryl
Halides Enabled by the Use of a Palladacycle Precatalyst |
title_sort | palladium-catalyzed hydroxylation
of aryl and heteroaryl
halides enabled by the use of a palladacycle precatalyst |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049244/ https://www.ncbi.nlm.nih.gov/pubmed/24762125 http://dx.doi.org/10.1021/jo500662s |
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