Cargando…

Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst

[Image: see text] A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheung, Chi Wai, Buchwald, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049244/
https://www.ncbi.nlm.nih.gov/pubmed/24762125
http://dx.doi.org/10.1021/jo500662s
_version_ 1782319795389071360
author Cheung, Chi Wai
Buchwald, Stephen L.
author_facet Cheung, Chi Wai
Buchwald, Stephen L.
author_sort Cheung, Chi Wai
collection PubMed
description [Image: see text] A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.
format Online
Article
Text
id pubmed-4049244
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-40492442015-04-24 Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst Cheung, Chi Wai Buchwald, Stephen L. J Org Chem [Image: see text] A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield. American Chemical Society 2014-04-24 2014-06-06 /pmc/articles/PMC4049244/ /pubmed/24762125 http://dx.doi.org/10.1021/jo500662s Text en Copyright © 2014 American Chemical Society
spellingShingle Cheung, Chi Wai
Buchwald, Stephen L.
Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst
title Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst
title_full Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst
title_fullStr Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst
title_full_unstemmed Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst
title_short Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst
title_sort palladium-catalyzed hydroxylation of aryl and heteroaryl halides enabled by the use of a palladacycle precatalyst
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049244/
https://www.ncbi.nlm.nih.gov/pubmed/24762125
http://dx.doi.org/10.1021/jo500662s
work_keys_str_mv AT cheungchiwai palladiumcatalyzedhydroxylationofarylandheteroarylhalidesenabledbytheuseofapalladacycleprecatalyst
AT buchwaldstephenl palladiumcatalyzedhydroxylationofarylandheteroarylhalidesenabledbytheuseofapalladacycleprecatalyst