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Plasma concentrations of D-dimer and outcome of in vitro fertilization
BACKGROUND: The activation of blood coagulation could contribute to the failure of in-vitro fertilization (IVF) techniques. The aim of this study was to assess the predictive value of D-dimer levels for pregnancy outcome in women undergoing IVF. FINDINGS: A prospective study was performed in 105 wom...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049404/ https://www.ncbi.nlm.nih.gov/pubmed/24914407 http://dx.doi.org/10.1186/1757-2215-7-58 |
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author | Di Nisio, Marcello Porreca, Ettore Di Donato, Valeria Tiboni, Gian Mario |
author_facet | Di Nisio, Marcello Porreca, Ettore Di Donato, Valeria Tiboni, Gian Mario |
author_sort | Di Nisio, Marcello |
collection | PubMed |
description | BACKGROUND: The activation of blood coagulation could contribute to the failure of in-vitro fertilization (IVF) techniques. The aim of this study was to assess the predictive value of D-dimer levels for pregnancy outcome in women undergoing IVF. FINDINGS: A prospective study was performed in 105 women undergoing IVF. D-dimer was measured before and one week after the administration of recombinant human chorionic gonadotropin (r-hCG). The primary outcome of the study was clinical pregnancy. The mean age was 36 years (range 26 to 43 years). The main indications for IVF were infertility due to a tubaric (n = 21, 20%) or male factor (n = 37, 35%) and idiopathic infertility (n = 30, 29%) which altogether accounted for 84% of the total. Clinical pregnancy was achieved by 40/105 (38%) women of whom 32 (80%) delivered a live child. On the day of r-hCG administration, D-dimer concentrations were significantly higher in patients not achieving a clinical pregnancy (141 ng/dL vs. 115 ng/dL, p = 0.035) which remained statistically significant after correction for age and indications for IVF in multivariable analysis (p = 0.032). One week after r-hCG, the levels of D-dimer were significantly increased both in women with and without a clinical pregnancy with no differences between the groups (748 ng/dL vs. 767 ng/dL, p = 0.88). CONCLUSIONS: D-dimer concentrations seem to predict a higher risk of pregnancy failure in women undergoing IVF. If confirmed in future prospective studies, D-dimer could help identifying a group of patients who could benefit from prophylaxis to increase the pregnancy success rate. |
format | Online Article Text |
id | pubmed-4049404 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40494042014-06-10 Plasma concentrations of D-dimer and outcome of in vitro fertilization Di Nisio, Marcello Porreca, Ettore Di Donato, Valeria Tiboni, Gian Mario J Ovarian Res Brief Communication BACKGROUND: The activation of blood coagulation could contribute to the failure of in-vitro fertilization (IVF) techniques. The aim of this study was to assess the predictive value of D-dimer levels for pregnancy outcome in women undergoing IVF. FINDINGS: A prospective study was performed in 105 women undergoing IVF. D-dimer was measured before and one week after the administration of recombinant human chorionic gonadotropin (r-hCG). The primary outcome of the study was clinical pregnancy. The mean age was 36 years (range 26 to 43 years). The main indications for IVF were infertility due to a tubaric (n = 21, 20%) or male factor (n = 37, 35%) and idiopathic infertility (n = 30, 29%) which altogether accounted for 84% of the total. Clinical pregnancy was achieved by 40/105 (38%) women of whom 32 (80%) delivered a live child. On the day of r-hCG administration, D-dimer concentrations were significantly higher in patients not achieving a clinical pregnancy (141 ng/dL vs. 115 ng/dL, p = 0.035) which remained statistically significant after correction for age and indications for IVF in multivariable analysis (p = 0.032). One week after r-hCG, the levels of D-dimer were significantly increased both in women with and without a clinical pregnancy with no differences between the groups (748 ng/dL vs. 767 ng/dL, p = 0.88). CONCLUSIONS: D-dimer concentrations seem to predict a higher risk of pregnancy failure in women undergoing IVF. If confirmed in future prospective studies, D-dimer could help identifying a group of patients who could benefit from prophylaxis to increase the pregnancy success rate. BioMed Central 2014-05-22 /pmc/articles/PMC4049404/ /pubmed/24914407 http://dx.doi.org/10.1186/1757-2215-7-58 Text en Copyright © 2014 Di Nisio et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Brief Communication Di Nisio, Marcello Porreca, Ettore Di Donato, Valeria Tiboni, Gian Mario Plasma concentrations of D-dimer and outcome of in vitro fertilization |
title | Plasma concentrations of D-dimer and outcome of in vitro fertilization |
title_full | Plasma concentrations of D-dimer and outcome of in vitro fertilization |
title_fullStr | Plasma concentrations of D-dimer and outcome of in vitro fertilization |
title_full_unstemmed | Plasma concentrations of D-dimer and outcome of in vitro fertilization |
title_short | Plasma concentrations of D-dimer and outcome of in vitro fertilization |
title_sort | plasma concentrations of d-dimer and outcome of in vitro fertilization |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049404/ https://www.ncbi.nlm.nih.gov/pubmed/24914407 http://dx.doi.org/10.1186/1757-2215-7-58 |
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