Cargando…

Plasma concentrations of D-dimer and outcome of in vitro fertilization

BACKGROUND: The activation of blood coagulation could contribute to the failure of in-vitro fertilization (IVF) techniques. The aim of this study was to assess the predictive value of D-dimer levels for pregnancy outcome in women undergoing IVF. FINDINGS: A prospective study was performed in 105 wom...

Descripción completa

Detalles Bibliográficos
Autores principales: Di Nisio, Marcello, Porreca, Ettore, Di Donato, Valeria, Tiboni, Gian Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049404/
https://www.ncbi.nlm.nih.gov/pubmed/24914407
http://dx.doi.org/10.1186/1757-2215-7-58
_version_ 1782319807455035392
author Di Nisio, Marcello
Porreca, Ettore
Di Donato, Valeria
Tiboni, Gian Mario
author_facet Di Nisio, Marcello
Porreca, Ettore
Di Donato, Valeria
Tiboni, Gian Mario
author_sort Di Nisio, Marcello
collection PubMed
description BACKGROUND: The activation of blood coagulation could contribute to the failure of in-vitro fertilization (IVF) techniques. The aim of this study was to assess the predictive value of D-dimer levels for pregnancy outcome in women undergoing IVF. FINDINGS: A prospective study was performed in 105 women undergoing IVF. D-dimer was measured before and one week after the administration of recombinant human chorionic gonadotropin (r-hCG). The primary outcome of the study was clinical pregnancy. The mean age was 36 years (range 26 to 43 years). The main indications for IVF were infertility due to a tubaric (n = 21, 20%) or male factor (n = 37, 35%) and idiopathic infertility (n = 30, 29%) which altogether accounted for 84% of the total. Clinical pregnancy was achieved by 40/105 (38%) women of whom 32 (80%) delivered a live child. On the day of r-hCG administration, D-dimer concentrations were significantly higher in patients not achieving a clinical pregnancy (141 ng/dL vs. 115 ng/dL, p = 0.035) which remained statistically significant after correction for age and indications for IVF in multivariable analysis (p = 0.032). One week after r-hCG, the levels of D-dimer were significantly increased both in women with and without a clinical pregnancy with no differences between the groups (748 ng/dL vs. 767 ng/dL, p = 0.88). CONCLUSIONS: D-dimer concentrations seem to predict a higher risk of pregnancy failure in women undergoing IVF. If confirmed in future prospective studies, D-dimer could help identifying a group of patients who could benefit from prophylaxis to increase the pregnancy success rate.
format Online
Article
Text
id pubmed-4049404
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-40494042014-06-10 Plasma concentrations of D-dimer and outcome of in vitro fertilization Di Nisio, Marcello Porreca, Ettore Di Donato, Valeria Tiboni, Gian Mario J Ovarian Res Brief Communication BACKGROUND: The activation of blood coagulation could contribute to the failure of in-vitro fertilization (IVF) techniques. The aim of this study was to assess the predictive value of D-dimer levels for pregnancy outcome in women undergoing IVF. FINDINGS: A prospective study was performed in 105 women undergoing IVF. D-dimer was measured before and one week after the administration of recombinant human chorionic gonadotropin (r-hCG). The primary outcome of the study was clinical pregnancy. The mean age was 36 years (range 26 to 43 years). The main indications for IVF were infertility due to a tubaric (n = 21, 20%) or male factor (n = 37, 35%) and idiopathic infertility (n = 30, 29%) which altogether accounted for 84% of the total. Clinical pregnancy was achieved by 40/105 (38%) women of whom 32 (80%) delivered a live child. On the day of r-hCG administration, D-dimer concentrations were significantly higher in patients not achieving a clinical pregnancy (141 ng/dL vs. 115 ng/dL, p = 0.035) which remained statistically significant after correction for age and indications for IVF in multivariable analysis (p = 0.032). One week after r-hCG, the levels of D-dimer were significantly increased both in women with and without a clinical pregnancy with no differences between the groups (748 ng/dL vs. 767 ng/dL, p = 0.88). CONCLUSIONS: D-dimer concentrations seem to predict a higher risk of pregnancy failure in women undergoing IVF. If confirmed in future prospective studies, D-dimer could help identifying a group of patients who could benefit from prophylaxis to increase the pregnancy success rate. BioMed Central 2014-05-22 /pmc/articles/PMC4049404/ /pubmed/24914407 http://dx.doi.org/10.1186/1757-2215-7-58 Text en Copyright © 2014 Di Nisio et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Brief Communication
Di Nisio, Marcello
Porreca, Ettore
Di Donato, Valeria
Tiboni, Gian Mario
Plasma concentrations of D-dimer and outcome of in vitro fertilization
title Plasma concentrations of D-dimer and outcome of in vitro fertilization
title_full Plasma concentrations of D-dimer and outcome of in vitro fertilization
title_fullStr Plasma concentrations of D-dimer and outcome of in vitro fertilization
title_full_unstemmed Plasma concentrations of D-dimer and outcome of in vitro fertilization
title_short Plasma concentrations of D-dimer and outcome of in vitro fertilization
title_sort plasma concentrations of d-dimer and outcome of in vitro fertilization
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049404/
https://www.ncbi.nlm.nih.gov/pubmed/24914407
http://dx.doi.org/10.1186/1757-2215-7-58
work_keys_str_mv AT dinisiomarcello plasmaconcentrationsofddimerandoutcomeofinvitrofertilization
AT porrecaettore plasmaconcentrationsofddimerandoutcomeofinvitrofertilization
AT didonatovaleria plasmaconcentrationsofddimerandoutcomeofinvitrofertilization
AT tibonigianmario plasmaconcentrationsofddimerandoutcomeofinvitrofertilization